CAJ | 학술논문

目的探讨肝硬化病人血、尿β2-微球蛋白升高的临床特点及与肾功能的关系。方法 56例肝硬化患者按Child分级标准分成3组，用放免法测定患者血、尿β2-微球蛋白。结果肝硬化病人血β2-微球蛋白较正常对照组明显升高，并且与肾小球滤过率下降有相关关系。尿β2-微球蛋白明显升高，且与肝功能损害程度有相关关系。结论大多数肝硬化患者血β2-微球蛋白都升高，并且与肾小球滤过率下降有关。在肝硬化早期即有尿β2-微球蛋白升高，并与肝功能损害程度有相关关系。尿β2-微球蛋白有助于及早判断肝硬化病人肾小管的损伤程度。
목적 탐토간경화병인혈、뇨β2-미구단백승고적림상특점급여신공능적관계。방법 56례간경화환자안Child분급표준분성3조，용방면법측정환자혈、뇨β2-미구단백。결과 간경화병인혈β2-미구단백교정상대조조명현승고，병차여신소구려과솔하강유상관관계。뇨β2-미구단백명현승고，차여간공능손해정도유상관관계。결론 대다수간경화환자혈β2-미구단백도승고，병차여신소구려과솔하강유관。재간경화조기즉유뇨β2-미구단백승고，병여간공능손해정도유상관관계。뇨β2-미구단백유조우급조판단간경화병인신소관적손상정도。
Objective To find out the characteristic and the relationsbetween β2-microglobin (β2-MG) in serum and urine and liver function in cirrhosis.Methods Serum and urine β2-MG level were detected in 56 patients with hepatocirrhosis by radioimmunoassay(RIA).56 patients were divided into three groups according to the Child-pugh score.Results Serum β2-MG level was higher in patients with cirrhosis than in control group,and serum β2-MG level correlated with glomerular filtration rate decrease.Urine β2-MG level showed significant increase in cirrhosis and correlated with liver function impairment.Conclusion Serum β2-MG level increased in most cirrhosis patients which related glomerular filtration rate.Urine β2-MG level had increased in the early phase of cirrhosis,and increased higher when the liver function decreased,which help us find out renal tubule damage in time.