CAJ | 학술논문

目的:研究花椒挥发油(EOZM)对离体来孕雌激素预处理小白鼠子宫平滑肌的作用及其可能的机制.方法:分别观察EOZM和维拉帕米(Vet)对催产素(OXT)和氯化钙(CaCl2)引起的子宫收缩的影响、对OXT诱导的依内钙性收缩和依外钙性收缩的影响.结果:EOZM和Ver均可抑制子宫自律性收缩以及OXT和CaCl2引起的子宫收缩而且具有剂量依赖性;EOZM对OXT诱导的依内钙性收缩和依外钙性收缩均有抑制作用;Ver仅对OXT诱导的依内钙性收缩有抑制作用,对OXT诱导的依外钙性收缩则没有影响.结论:EOZM可能主要通过阻断受体调控的钙通道(ROC)和电压依赖的钙通道(VDC),减少外钙内流和内钙释放从而抑制小白鼠子宫平滑肌的收缩.
목적:연구화초휘발유(EOZM)대리체래잉자격소예처리소백서자궁평활기적작용급기가능적궤제.방법:분별관찰EOZM화유랍파미(Vet)대최산소(OXT)화록화개(CaCl2)인기적자궁수축적영향、대OXT유도적의내개성수축화의외개성수축적영향.결과:EOZM화Ver균가억제자궁자률성수축이급OXT화CaCl2인기적자궁수축이차구유제량의뢰성;EOZM대OXT유도적의내개성수축화의외개성수축균유억제작용;Ver부대OXT유도적의내개성수축유억제작용,대OXT유도적의외개성수축칙몰유영향.결론:EOZM가능주요통과조단수체조공적개통도(ROC)화전압의뢰적개통도(VDC),감소외개내류화내개석방종이억제소백서자궁평활기적수축.
Objective:To study the effects of EOZM on contraction of uterine smootymuscle treated by estrogen of Mus musculus albusand its possible mechanism.Methods:To observe the effects of EoZM and Ver on contraction induced by OXT and CaCl2 and on intracellUlar and extracellUlar calCium dependent oontraction induccd by OXT respectvely.Results:Both EOZM and Ver COUld inhibit the contraction induced by OXT and CaCl2 and intracellular calcium dependent contraction induced by OXT and the effects are does dependent.EOZM also inhibied extracellular Calcium dependent contraction induced by OXT but Ver not.Conclusions,EOZM inhibits the contraction of uterus mainly by blocking ROC and VDC and consequently decreasing influx Of extracellular calCium and decreasing release of intracellular Calcivm.