国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2011年
21期
1618-1620
,共3页
宋冰%李志莹%巫翠华%周燕宁%聂丽%陈立波%洪永忠%钟春%黄平
宋冰%李誌瑩%巫翠華%週燕寧%聶麗%陳立波%洪永忠%鐘春%黃平
송빙%리지형%무취화%주연저%섭려%진립파%홍영충%종춘%황평
氮氧化物%2型糖尿病%呼出气冷凝液%肺功能
氮氧化物%2型糖尿病%呼齣氣冷凝液%肺功能
담양화물%2형당뇨병%호출기냉응액%폐공능
Nitrogen oxides%Type 2 diabetes%Exhaled breath condansate%Lung function
目的 观察2型糖尿病患者呼出气冷凝液(EBC)中氮氧化物的改变,为诊断2型糖尿病肺损害提供新方法.方法 试验共纳入36例2型糖尿病患者和31名健康者,用Rtube收集器收集EBC,用分光光度法检测EBC中氮氧化物(NO2-、NO3-、总NO2-/NO3-),同时记录肺功能.结果 2型糖尿病患者EBC中NO2-、总NO2-/NO3浓度水平高于健康对照组(P＜0.05或P＜0.01)；2型糖尿病肺功能第1秒用力呼气量(FEV1)占预计值％、肺一氧化碳弥散量(DLCO)、DLCO占预计值％比健康对照组降低(P值均＜0.05)；2型糖尿病组EBC中NO2-的浓度及总NO2/NO3ˉ与FEV1占预计值％、DLCO、DLCO占预计值％有相关性(P ＜0.05或P＜0.01).结论 EBC中氮氧化物在2型糖尿病肺损害的发病中起重要作用.
目的 觀察2型糖尿病患者呼齣氣冷凝液(EBC)中氮氧化物的改變,為診斷2型糖尿病肺損害提供新方法.方法 試驗共納入36例2型糖尿病患者和31名健康者,用Rtube收集器收集EBC,用分光光度法檢測EBC中氮氧化物(NO2-、NO3-、總NO2-/NO3-),同時記錄肺功能.結果 2型糖尿病患者EBC中NO2-、總NO2-/NO3濃度水平高于健康對照組(P＜0.05或P＜0.01)；2型糖尿病肺功能第1秒用力呼氣量(FEV1)佔預計值％、肺一氧化碳瀰散量(DLCO)、DLCO佔預計值％比健康對照組降低(P值均＜0.05)；2型糖尿病組EBC中NO2-的濃度及總NO2/NO3ˉ與FEV1佔預計值％、DLCO、DLCO佔預計值％有相關性(P ＜0.05或P＜0.01).結論 EBC中氮氧化物在2型糖尿病肺損害的髮病中起重要作用.
목적 관찰2형당뇨병환자호출기냉응액(EBC)중담양화물적개변,위진단2형당뇨병폐손해제공신방법.방법 시험공납입36례2형당뇨병환자화31명건강자,용Rtube수집기수집EBC,용분광광도법검측EBC중담양화물(NO2-、NO3-、총NO2-/NO3-),동시기록폐공능.결과 2형당뇨병환자EBC중NO2-、총NO2-/NO3농도수평고우건강대조조(P＜0.05혹P＜0.01)；2형당뇨병폐공능제1초용력호기량(FEV1)점예계치％、폐일양화탄미산량(DLCO)、DLCO점예계치％비건강대조조강저(P치균＜0.05)；2형당뇨병조EBC중NO2-적농도급총NO2/NO3ˉ여FEV1점예계치％、DLCO、DLCO점예계치％유상관성(P ＜0.05혹P＜0.01).결론 EBC중담양화물재2형당뇨병폐손해적발병중기중요작용.
Objective To observe the changes of nitrogen oxides in the exhaled breath condensates (EBC) of patients with type 2 diabetes,and to provide a new method for the diagnosis of lung injury in type 2 diabetes.Methods 36 patients with type 2 diabetes and 31 healthy people were recruited.The pulmonary function tests were evaluated.Nitrogen oxides in EBC were measured by the spectrophotometry and nitric oxide assay kit.Results The concentrations of NO2ˉ and NO2ˉ/NO3ˉ in EBC of type 2 diabetes patients were higher than those in healthy group (P ＜ 0.05 or P ＜ 0.01).FEV1 ％pred,DLCO and DLCO ％pred of type 2 diabetes patients were lower than those of healthy group (all P ＜0.05).The concentrations of NO2ˉand NO2ˉ/NO3ˉ in EBC of type 2 diabetes patients were relative with FEV1 ％ pred,DLCO and DLCO ％ pred ( P ＜0.05 or P ＜0.01).Conclusions Nitrogen oxides in EBC may play an important role in the pathogenesis of the lung injury of type 2 diabetes patients.
