中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2012年
12期
21-23
,共3页
苦参%卵巢肿瘤%药物疗法
苦參%卵巢腫瘤%藥物療法
고삼%란소종류%약물요법
Sophora flavescens%Ovarian neoplasms%Drug therapy
目的 研究复方苦参注射液联合化疗在晚期卵巢癌中的综合疗效.方法 将86例晚期卵巢癌患者按随机数字表法分为观察组和对照组,每组43例.观察组采用顺铂+紫杉醇化疗方案并加复方苦参注射液,对照组仅采用顺铂+紫杉醇化疗方案.观察两组患者治疗前后白细胞的变化、不良反应及疗效.结果 观察组治疗后白细胞明显高于对照组[ (4.7±1.4)×109/L比(3.2±1.6)×109/L,P＜0.05]；观察组恶心呕吐、转氨酶升高、肾功能损害发生率明显低于对照组[16.3％(7/43)、14.0％(6/43)、20.9％(9/43)比34.9％(15/43)、32.6％( 14/43)、44.2％( 19/43),P＜ 0.05]；观察组完全缓解率明显高于对照组[ 55.8％( 24/43)比27.9％(12/43),P＜0.05].结论 复方苦参注射液能较好地保护卵巢癌化疗患者的白细胞不下降、减轻化疗的不良反应,提高疗效.
目的 研究複方苦參註射液聯閤化療在晚期卵巢癌中的綜閤療效.方法 將86例晚期卵巢癌患者按隨機數字錶法分為觀察組和對照組,每組43例.觀察組採用順鉑+紫杉醇化療方案併加複方苦參註射液,對照組僅採用順鉑+紫杉醇化療方案.觀察兩組患者治療前後白細胞的變化、不良反應及療效.結果 觀察組治療後白細胞明顯高于對照組[ (4.7±1.4)×109/L比(3.2±1.6)×109/L,P＜0.05]；觀察組噁心嘔吐、轉氨酶升高、腎功能損害髮生率明顯低于對照組[16.3％(7/43)、14.0％(6/43)、20.9％(9/43)比34.9％(15/43)、32.6％( 14/43)、44.2％( 19/43),P＜ 0.05]；觀察組完全緩解率明顯高于對照組[ 55.8％( 24/43)比27.9％(12/43),P＜0.05].結論 複方苦參註射液能較好地保護卵巢癌化療患者的白細胞不下降、減輕化療的不良反應,提高療效.
목적 연구복방고삼주사액연합화료재만기란소암중적종합료효.방법 장86례만기란소암환자안수궤수자표법분위관찰조화대조조,매조43례.관찰조채용순박+자삼순화료방안병가복방고삼주사액,대조조부채용순박+자삼순화료방안.관찰량조환자치료전후백세포적변화、불량반응급료효.결과 관찰조치료후백세포명현고우대조조[ (4.7±1.4)×109/L비(3.2±1.6)×109/L,P＜0.05]；관찰조악심구토、전안매승고、신공능손해발생솔명현저우대조조[16.3％(7/43)、14.0％(6/43)、20.9％(9/43)비34.9％(15/43)、32.6％( 14/43)、44.2％( 19/43),P＜ 0.05]；관찰조완전완해솔명현고우대조조[ 55.8％( 24/43)비27.9％(12/43),P＜0.05].결론 복방고삼주사액능교호지보호란소암화료환자적백세포불하강、감경화료적불량반응,제고료효.
Objective To evaluate the effect of compound oxymatrine injection combination with chemotherapy in patients with advanced ovarian carcinoma.Methods Eighty-six patients with advanced ovarian carcinoma were divided by random digits table method into observation group (43 cases) receiving compound oxymatrine injection plus chemotherapy (paclitaxel plus carboplatin) and control group (43cases) treated with chemotherapy (p aclitaxel plus carboplatin) alone.The change of white blood cell,adverse reaction and effect of the patients were observed.Results The white blood cell of observation group after treatment was obviously higher than that of control group [ (4.7 ± 1.4) × 109/L vs.(3.2 ± 1.6) × 109/L,P ＜ 0.05 ].The rates of nausea and vomiting,transaminase elevating and kidney damage of observation group were obviously lower than those of control group [ 16.3％ (7/43),14.0％ (6/43),20.9％ (9/43) vs.34.9％(15/43),32.6％ (14/43),44.2％ ( 19/43 ),P ＜ 0.05 ].The complete remission rate of observation group was significantly higher than that of control group [55.8％(24/43) vs.27.9％(12/43),P ＜ 0.05].Conclusion Addition of compound oxymatrine injection to chemotherapy for patients with advanced ovarian carcinoma can effectively protect patients against the decreasing of the white blood cell and attenuate the side effects brought by chemotherapy.
