CAJ | 학술논문

白藜芦醇是一种含有芪类结构的非黄酮类多酚化合物,它不仅是植物抗毒素,还具有抗癌、抗氧化、调节血脂等多种功能.体内外实验表明,白藜芦醇对黑素瘤起始、增殖、发展3个主要阶段均有抑制甚至逆转作用.其抗黑素瘤机制可以通过阻滞细胞周期、抗氧化、促进肿瘤细胞凋亡、诱导肿瘤细胞分化、干扰相关信号转导通路、抑制肿瘤血管生成等方面发挥作用.
백려호순시일충함유기류결구적비황동류다분화합물,타불부시식물항독소,환구유항암、항양화、조절혈지등다충공능.체내외실험표명,백려호순대흑소류기시、증식、발전3개주요계단균유억제심지역전작용.기항흑소류궤제가이통과조체세포주기、항양화、촉진종류세포조망、유도종류세포분화、간우상관신호전도통로、억제종류혈관생성등방면발휘작용.
Resveratrol, as a non-flavonoid polyphenolic compound,is not only a phytoalexin in plants,but also has antioxidant,anti-tumor,lipid-regulating activity.Recent in vivo and vitro studies have demonstrated that resveratrol can inhibit and even reverse melanoma initiation, promotion and progression.The anti-tumor effects of resveratrol may be mediated by resisting oxadation, blocking cell cycles, promoting apoptosis and inducing differentiation of tumor cells,interfering related signal transduction and inhibiting angiogenesis.