CAJ | 학술논문

目的探讨重度子癎前期合并低蛋白血症对围产结局的影响及其相关性.方法回顾性分析我院2000年1月至2006年3月收治的233例重度子痢前期患者的临床资料,按血清白蛋白检测结果将其分成低蛋白血症组(A组,133例)和非低蛋白血症组(B组,90例),比较两组孕产妇及围产儿结局.结果 A组孕妇浆膜腔积液(6.8%和0)、肝酶异常(60.9 %和38.9%)、肾功损害(30.1%和11.1%)及并发症(胎盘早剥、产后出血)的发生率(23.3%和11.1%)均高于B组(P<0.05),新生儿出生体重低于B组[(2192.78±795.31)g和(2454.92±776.24)g,P<0.05],围产儿死亡率A组高于B组(26.0%和13.5%)(P<0.05).结论重度子痢前期合并低蛋白血症可造成母儿的不良结局,应积极防治.充分细致评估母胎状况,尽可能延长孕周改善新生儿结局,若孕妇重要器官受损或并发难治性浆膜腔积液应适时终止妊娠,以改善孕母结局.
목적 탐토중도자간전기합병저단백혈증대위산결국적영향급기상관성.방법 회고성분석아원2000년1월지2006년3월수치적233례중도자리전기환자적림상자료,안혈청백단백검측결과장기분성저단백혈증조(A조,133례)화비저단백혈증조(B조,90례),비교량조잉산부급위산인결국.결과 A조잉부장막강적액(6.8%화0)、간매이상(60.9 %화38.9%)、신공손해(30.1%화11.1%)급병발증(태반조박、산후출혈)적발생솔(23.3%화11.1%)균고우B조(P<0.05),신생인출생체중저우B조[(2192.78±795.31)g화(2454.92±776.24)g,P<0.05],위산인사망솔A조고우B조(26.0%화13.5%)(P<0.05).결론 중도자리전기합병저단백혈증가조성모인적불량결국,응적겁방치.충분세치평고모태상황,진가능연장잉주개선신생인결국,약잉부중요기관수손혹병발난치성장막강적액응괄시종지임신,이개선잉모결국.
Objective To explore the effects of low serum-albumin on maternal and neonatal outcomes in severe pre-eclampsia. Methods Two hundred and thirty-three women with severe preeclampsia admitted to our hospital from Jan. 2000 to Mar. 2006 were retrospectively investigated and were divided into two groups according to the serum-albumin level: low serum-albumin group (Group A, n= 133) and normal serum-albumin group (Group B, n=90). Maternal and fetal outcomes were compared between the two groups. Results The proportion of women with abnormal retention of fluid (6.8%, vs 0), elevated liver enzymes (60.9% vs 38.9%) renal involvement (30.1% vs 11.1%) and complications (23.3% vs 11.1%) (placental abruption and postpartum hemorrhage) in group A were significantly higher than those in group B (all P<0. 05). Birth weight in group A was lower than that in group B[(2192. 78±795. 31) g vs (2454. 92±776. 24) g, P<0. 05] and neonatal mortality in group A was higher (26.0%vs 13. 6%, P<0. 05). Conclusions Severe pre-eclampsia with low serum-albumin is associated with severe maternal and neonatal outcomes. Appropriate termination of pregnancy should be considered following adequate and careful assessment of maternal and fetal well-being in order to improve perinatal outcomes.