CAJ | 학술논문

目的研究大蒜新素对宫颈病变组织HPV16 E7基因表达的影响.方法运用PCR技术检测宫颈病变组织HPV16 E7基因,表达阳性的患者160例,随机分为安慰剂组、大蒜新素治疗组和阿昔洛韦治疗组,观察治疗前后宫颈病变情况及HPV转阴率.结果治疗后大蒜新素治疗组、阿昔洛韦治疗组宫颈局部情况转为正常者与安慰剂组相比差异有统计学意义(P<0.05);大蒜新素治疗组与阿昔洛韦治疗组的HPV转阴率比较差异无统计学意义(P>0.05);大蒜新素治疗组与安慰剂组,阿昔洛韦治疗组与安慰剂组的HPV转阴率比较差异均有统计学意义(P<0.05).结论大蒜新素治疗后宫颈病变情况减轻,局部组织结构恢复正常,机体的病毒清除率大有提高,值得临床推广应用.
목적 연구대산신소대궁경병변조직HPV16 E7기인표체적영향.방법 운용PCR기술검측궁경병변조직HPV16 E7기인,표체양성적환자160례,수궤분위안위제조、대산신소치료조화아석락위치료조,관찰치료전후궁경병변정황급HPV전음솔.결과 치료후대산신소치료조、아석락위치료조궁경국부정황전위정상자여안위제조상비차이유통계학의의(P<0.05);대산신소치료조여아석락위치료조적HPV전음솔비교차이무통계학의의(P>0.05);대산신소치료조여안위제조,아석락위치료조여안위제조적HPV전음솔비교차이균유통계학의의(P<0.05).결론 대산신소치료후궁경병변정황감경,국부조직결구회복정상,궤체적병독청제솔대유제고,치득림상추엄응용.
Objective To investigate the effect of allitridin on the expression of HPV16 E7 protein in cervical lesions. Methods PCR was applied to examine DNA of HPV16 E7 in cervical lesions. One hundred and sixty samples were proved HPV16 E7 positive. Positive samples were randomly divided into three groups: group A(control), group B(allitridin) and group C(caciclovir). The changes in cervical lesions and the changes of HPV16 E7 protein were observed. Results The changes in cervical lesions of groups B and C were significantly higher than that in group A (P＜0.05). In comparison with groups B and A, the expression of HPV16 E7 was decreased significantly(P＜0.05). The expression of HPV16 E7 of group C was significantly lower than that in group A(P＜0.05). However, the negative rate of HPV16 E7 of groups B and C were 56%, 65%,respectively,which was no significantly. Conclusions Allitridin can diminished significantly cervical lesions. And allitridin can down-regulate the expression of HPV16 E7 protein in cervical lesions.