佳木斯大学学报：自然科学版
佳木斯大學學報：自然科學版
가목사대학학보：자연과학판
Journal of Jiamusi University(Natural Science Edition)
2011年
4期
615-618
,共4页
刘翠娟%慎爱民%韩德强%杨治伟%张云萍%于敏%吕玉光
劉翠娟%慎愛民%韓德彊%楊治偉%張雲萍%于敏%呂玉光
류취연%신애민%한덕강%양치위%장운평%우민%려옥광
甲氨蝶呤%水滑石%体外释放
甲氨蝶呤%水滑石%體外釋放
갑안접령%수활석%체외석방
Methotrexate%layered double hydroxides%release in vitro
采用焙烧复原法和离子交换法将甲氨蝶呤（MTX）插层组装到水滑石层间,制备了一种新型的甲氨蝶呤柱撑水滑石抗肿瘤药物-无机复合层柱材料.通过XRD,FT/IR对产物分析表征,并对其在不同pH条件下的体外释放性能进行了研究.
採用焙燒複原法和離子交換法將甲氨蝶呤（MTX）插層組裝到水滑石層間,製備瞭一種新型的甲氨蝶呤柱撐水滑石抗腫瘤藥物-無機複閤層柱材料.通過XRD,FT/IR對產物分析錶徵,併對其在不同pH條件下的體外釋放性能進行瞭研究.
채용배소복원법화리자교환법장갑안접령（MTX）삽층조장도수활석층간,제비료일충신형적갑안접령주탱수활석항종류약물-무궤복합층주재료.통과XRD,FT/IR대산물분석표정,병대기재불동pH조건하적체외석방성능진행료연구.
A new drug-inorganic composite involving an antitumor drug methotrexate（MTX） intercalated layered double hydroxides was assembled by calcine-recovering method and ion-exchange methods.The structures of materials were characterized by powder X-ray diffraction and FT-IR spectra.And the properties of releasing in vitro in different pH value were explored.
