CAJ | 학술논문

目的探讨前列腺干细胞抗原(PSCA)在人胰腺癌神经浸润中的作用.方法80例胰腺癌手术标本切片行HE染色,观察记数小血管、小淋巴管、神经纤维浸润数.用鼠抗人PSCA单抗行免疫组化(Elivison二步法)染色,观察肿瘤细胞的阳性情况.结果肿瘤细胞神经浸润阳性与小血管、小淋巴管的浸润呈正相关(P<0.01);肿瘤细胞PSCA表达阳性(53例)与神经浸润阳性(66例)呈正相关(P<0.01);肿瘤的恶性程度与PSCA表达呈正相关;PSCA表达与小血管、小淋巴管浸润无关.结论PSCA可能是胰腺癌的特征性分子之一,可引导胰腺癌细胞向神经纤维趋化和黏附,即起"导航"和"停泊"作用.
목적탐토전렬선간세포항원(PSCA)재인이선암신경침윤중적작용.방법80례이선암수술표본절편행HE염색,관찰기수소혈관、소림파관、신경섬유침윤수.용서항인PSCA단항행면역조화(Elivison이보법)염색,관찰종류세포적양성정황.결과종류세포신경침윤양성여소혈관、소림파관적침윤정정상관(P<0.01);종류세포PSCA표체양성(53례)여신경침윤양성(66례)정정상관(P<0.01);종류적악성정도여PSCA표체정정상관;PSCA표체여소혈관、소림파관침윤무관.결론PSCA가능시이선암적특정성분자지일,가인도이선암세포향신경섬유추화화점부,즉기"도항"화"정박"작용.
Objective To investigate the role of the expression of prostate stem cell antigen(PSCA)in the development of perineural invasion in pancreatic carcinoma.Methods The histopathologic and immunohis-tochemical(SABC)studies were performed on 80 patients with pancreatic carcinoma.The overall incidence of PSCA expression,perineural,lymphatic and vascular vessel invasion were counted to investigate the relationships among them.Results Perineurel invasion was positively correlated with lymphatic and vascular vessel invasion (P<0.01).A positive corelation Was found between tumor PSCA expressioa(53 cases)and the perineurel in-vasion(66 cases).A definite correlation Was also found between cancer differentiation and PSCA tyxplres-sion.Conclusion PSCA is one of the most important molecules and may play a role as a "navigating" and " docking" molecule in the developmeat of perineural invasion.