CAJ | 학술논문

腺苷广泛分布于全身各组织器官,可通过与细胞表面相应G-蛋白偶联受体结合发挥抑制炎症反应,对抗缺血/缺氧和免疫调节等生物学作用.目前发现腺苷受体有4种亚型,即A1R、A2aR、A2bR和A3R.其中A2a腺苷受体(A2aR)广泛分布于神经胶质细胞,巨噬细胞,树突状细胞,肥大细胞,自然杀伤细胞等免疫细胞及内皮细胞和上皮细胞中,在相应的腺苷配体作用下,可通过腺苷-腺苷受体系统介导炎症反应和发挥免疫调节作用.
선감엄범분포우전신각조직기관,가통과여세포표면상응G-단백우련수체결합발휘억제염증반응,대항결혈/결양화면역조절등생물학작용.목전발현선감수체유4충아형,즉A1R、A2aR、A2bR화A3R.기중A2a선감수체(A2aR)엄범분포우신경효질세포,거서세포,수돌상세포,비대세포,자연살상세포등면역세포급내피세포화상피세포중,재상응적선감배체작용하,가통과선감-선감수체계통개도염증반응화발휘면역조절작용.
Adenosine has a wide distribution in organs and tissues of the human body. It plays diverse physio-logical roles including the inhibition of inflammatory reactions, the resistance of ischemia/hypoxia and the mod-ulation of immunological reactions through binding with G-protein-coupled receptors on cell surfaces. There are four kinds of adenosine receptors, A1R,A2aR,A2bR and A3R. A2aR is widely expressed in virtually all cell typos involving in inflammatory/immune responses. These cell types include glial cells, macrophages, dendritic cells, mast cells, NK cells, endothelial cells, as well as epithelial cells. A2aR serves to regulate conventional inflammatory reactions and immunological reactions.