CAJ | 학술논문

目的观察缺血性脑血管病患者急性期血浆溶血磷脂酸(LPA)水平的动态变化,探讨LPA在缺血性脑血管病急性期的意义.方法随机选择缺血性脑血管病住院患者103例,分为短暂性脑缺血发作(TIA)组、脑血栓形成组和腔隙性脑梗死组,测定发病后第1、2、3、7天及健康对照组血浆LPA含量.结果 TIA组、脑血栓形成组和腔隙性脑梗死组患者血浆LPA水平均显著高于健康对照组(P<0.01),于发病后24h内开始升高,呈时间动态变化过程.结论 LPA与缺血性脑血管病的发生发展密切相关,对指导临床治疗及预防有重要意义.
목적 관찰결혈성뇌혈관병환자급성기혈장용혈린지산(LPA)수평적동태변화,탐토LPA재결혈성뇌혈관병급성기적의의.방법 수궤선택결혈성뇌혈관병주원환자103례,분위단잠성뇌결혈발작(TIA)조、뇌혈전형성조화강극성뇌경사조,측정발병후제1、2、3、7천급건강대조조혈장LPA함량.결과 TIA조、뇌혈전형성조화강극성뇌경사조환자혈장LPA수평균현저고우건강대조조(P<0.01),우발병후24h내개시승고,정시간동태변화과정.결론 LPA여결혈성뇌혈관병적발생발전밀절상관,대지도림상치료급예방유중요의의.
Objective To observe the dynamic change of lysophosphatidic acid(LPA)level in plasma of pa- tients with acute ischemic cerebrovascular disease,and to find the significance of LPA.Methods We examined LPA level in fresh plasma of 103 patients with transient iscbemia attack,cerebral thrombosis or lacuna infarct at 1st day,2nd day,3rd day and 7th day after onset of the disease.We also examined the plasma of 30 heahhy controls.Results An elevated LPA level was seen in cases with ischemic cerebrovascular disease compared with healthy controls.Meanwhile,LPA level was related with the time after onset of the disease.Conclusion LPA plays an important role in the process of acute ischemic cerebrovaseular disease,and LPA level may be significant for clinical therapy and prognosis of acute ischemic cerebrovaacular disease.