CAJ | 학술논문

目的探讨活动期系统性红斑狼疮(SLE)患者血脂水平变化与脏器损害的关系.方法收集71例活动期SLE患者和30名健康对照者临床资料,分析血脂变化.结果活动期SLE患者平均血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL)、载脂蛋白B100(apoB)水平均高于健康对照组,高密度脂蛋白胆固醇(HDL)、apoA1水平显著低于健康对照组(P<0.05或P<0.01).有重要脏器损害患者的病程较长,血清TC、TG、LDL和apoB水平显著高于无脏器损害患者(P<0.05或P<0.01),尤其并发心血管病患者更明显(P<0.01).TC、TG、LDL、apoB水平与病程呈正相关(P<0.05或P<0.01),与C3水平呈负相关(P<0.05或P<0.01),TC和LDL与C4水平呈负相关(P<0.05).结论活动期SLE患者存在严重脂代谢紊乱,且脂代谢紊乱与病程、疾病活动性和重要脏器损害密切相关.
목적 탐토활동기계통성홍반랑창(SLE)환자혈지수평변화여장기손해적관계.방법 수집71례활동기SLE환자화30명건강대조자림상자료,분석혈지변화.결과 활동기SLE환자평균혈청총담고순(TC)、감유삼지(TG)、저밀도지단백(LDL)、재지단백B100(apoB)수평균고우건강대조조,고밀도지단백담고순(HDL)、apoA1수평현저저우건강대조조(P<0.05혹P<0.01).유중요장기손해환자적병정교장,혈청TC、TG、LDL화apoB수평현저고우무장기손해환자(P<0.05혹P<0.01),우기병발심혈관병환자경명현(P<0.01).TC、TG、LDL、apoB수평여병정정정상관(P<0.05혹P<0.01),여C3수평정부상관(P<0.05혹P<0.01),TC화LDL여C4수평정부상관(P<0.05).결론 활동기SLE환자존재엄중지대사문란,차지대사문란여병정、질병활동성화중요장기손해밀절상관.
Objective To investigate the correlation between dyslipidemia and important organ damage in patients with active systemic lupus erythematosus (SLE) without treatment. Methods Serum sam-ples from 71 active SLE patients and 30 healthy controls were obtained to measure lipid profiles including total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), apolipoproteinA1 (apoA1), apolipoproteinB100 (apoB) and lipoprotein a (LPa). Clinical parameters were recorded. Results The levels of serum TC, TG, LDL, apoB in active SLE patients were higher than those in healthy controls, in contrast,the levels of HDL,apoA1 were much lower (P<0.05 or P<0.01). Patients with important organ damages had longer disease course and elevated levels of serum TC, TG, LDL and apoB concentrations than those without organ damage (P<0.05 or P<0.01), especially in patients with cadiovascular diseases (CVD) (P<0.01). Moreover, these changes in lipid metabolism were positively correl-ated with disease course and negatively with C3 level (P<0.05 or P<0.01). The elevated serum TC and LDL concentrations were negatively correlated with C4 level (P<0.05). Conclusion Severe dyslipidemia is present in active SLE patients.It is correlated with disease course and disease activity. Increased serum TC, TG, LDL and apoB concentrations play key roles in patients with important organ damages.