北京中医药大学学报
北京中醫藥大學學報
북경중의약대학학보
JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
2009年
12期
856-858
,共3页
丹参%丹酚酸B%温度%稳定性
丹參%丹酚痠B%溫度%穩定性
단삼%단분산B%온도%은정성
Danshen(Radix Salviae Miltiorrhizae)%salvianolic acid B%temperature%stability
目的 研究温度对丹酚酸B在水溶液中稳定性的影响.方法 采用经典恒温加速试验法考察丹酚酸B在对照品水溶液中和丹参水提液中的含量变化,对比两条件下的试验结果;通过各条件下浓度的自然对数InC与时间t作图,确定丹酚酸B随温度降解的反应级数;预测各温度下的半衰期(t_(1/2))及有效期(t_(0.9)).结果 2种条件下丹酚酸B的含量均随温度的变化符合一级动力学方程,温度升高而含量降低,且丹酚酸B对照品溶液中降解速度明显高于丹参水提液.结论 丹酚酸B在不同温度下稳定性差别较大,制备制剂过程中应给予足够的重视.
目的 研究溫度對丹酚痠B在水溶液中穩定性的影響.方法 採用經典恆溫加速試驗法攷察丹酚痠B在對照品水溶液中和丹參水提液中的含量變化,對比兩條件下的試驗結果;通過各條件下濃度的自然對數InC與時間t作圖,確定丹酚痠B隨溫度降解的反應級數;預測各溫度下的半衰期(t_(1/2))及有效期(t_(0.9)).結果 2種條件下丹酚痠B的含量均隨溫度的變化符閤一級動力學方程,溫度升高而含量降低,且丹酚痠B對照品溶液中降解速度明顯高于丹參水提液.結論 丹酚痠B在不同溫度下穩定性差彆較大,製備製劑過程中應給予足夠的重視.
목적 연구온도대단분산B재수용액중은정성적영향.방법 채용경전항온가속시험법고찰단분산B재대조품수용액중화단삼수제액중적함량변화,대비량조건하적시험결과;통과각조건하농도적자연대수InC여시간t작도,학정단분산B수온도강해적반응급수;예측각온도하적반쇠기(t_(1/2))급유효기(t_(0.9)).결과 2충조건하단분산B적함량균수온도적변화부합일급동역학방정,온도승고이함량강저,차단분산B대조품용액중강해속도명현고우단삼수제액.결론 단분산B재불동온도하은정성차별교대,제비제제과정중응급여족구적중시.
Objective To study the influence of temperature on the stability of salvianolic acid B in water solution.Methods The content changes of salvianolic acid B in control solution and water extract solution of Danshen(Radix Salviae Miltiorrhizae)were observed by applying the classic isothermal accelerated test.The results were compared in two experimental conditions.The order of reaction of salvianolic acid B along with temperature degradation was determined through mapping natural logarithm and time(lnC-t),and t_(1/2) and t_(0.9) were predicted at different temperature.Results In two experimental conditions the content of salvianolic acid B accorded with the first-order kinetics equation with the changes of temperature.When temperature increased the content of salvianolic acid B decreased.The degradation speed of salvianolic acid B was higher in the control solution than that in the water extract solution of Danshen.Conclusion The stability of salvianolic acid B is very different at different temperature,which needs more attention in preparing course of the preparation containing salvianolic acid B.
