中国中西医结合杂志
中國中西醫結閤雜誌
중국중서의결합잡지
CHINESE JOURNAL OF INTEGRATED TRADITIONAL AND WESTERN MEDICINE
2010年
2期
201-204
,共4页
肿瘤微环境免疫%血管正常化时间窗%扶正培本%中药抗血管生成疗效评价
腫瘤微環境免疫%血管正常化時間窗%扶正培本%中藥抗血管生成療效評價
종류미배경면역%혈관정상화시간창%부정배본%중약항혈관생성료효평개
immunity in tumor microenvironment%normalization window for tumor vasculature%supporting body resistance%evaluation on therapeutic effect of antiangiogenic therapy with the traditional Chinese drug
"血管正常化时间窗"的发现是目前抗肿瘤血管生成领域研究的热点之一.将现代肿瘤微环境学说与抗肿瘤血管生成领域研究热点相结合,提出应用扶正培本治则方药调节肿瘤微环境免疫与血管的正常化的理论构想,主张通过扶正培本为主导的中药复方对肿瘤"微环境免疫与血管正常化"的调节作用与机制研究,探索中晚期非小细胞肺癌中医药抗血管生成治疗"血管正常化时间窗",为阐明扶正培本方药为主导的抗肿瘤侵袭与转移机制,联合放化疗最佳时机的选择,中医药抗血管生成疗效评价方法,提供初步的理论与实验依据,指导临床用药.
"血管正常化時間窗"的髮現是目前抗腫瘤血管生成領域研究的熱點之一.將現代腫瘤微環境學說與抗腫瘤血管生成領域研究熱點相結閤,提齣應用扶正培本治則方藥調節腫瘤微環境免疫與血管的正常化的理論構想,主張通過扶正培本為主導的中藥複方對腫瘤"微環境免疫與血管正常化"的調節作用與機製研究,探索中晚期非小細胞肺癌中醫藥抗血管生成治療"血管正常化時間窗",為闡明扶正培本方藥為主導的抗腫瘤侵襲與轉移機製,聯閤放化療最佳時機的選擇,中醫藥抗血管生成療效評價方法,提供初步的理論與實驗依據,指導臨床用藥.
"혈관정상화시간창"적발현시목전항종류혈관생성영역연구적열점지일.장현대종류미배경학설여항종류혈관생성영역연구열점상결합,제출응용부정배본치칙방약조절종류미배경면역여혈관적정상화적이론구상,주장통과부정배본위주도적중약복방대종류"미배경면역여혈관정상화"적조절작용여궤제연구,탐색중만기비소세포폐암중의약항혈관생성치료"혈관정상화시간창",위천명부정배본방약위주도적항종류침습여전이궤제,연합방화료최가시궤적선택,중의약항혈관생성료효평개방법,제공초보적이론여실험의거,지도림상용약.
Antiangiogenic therapy can generate a "normalization window" for tumor vasculature. This normalization process prunes immature vessels and improves the integrity and function of the remaining vasculature by enhancing the perivascular cell and basement membrane coverage in tumor,therefor creates a window of opportunity for improved sensitivity to ionizing radiation and the delivery of chemotherapeutic drugs. It provides a rational basis for the combination therapy of traditional Chinese drugs with radiation and perhaps other forms of chemotherapy. Antiangiogenic therapy with the traditional Chinese drug interfering in the the mechanisms of the normalization window in humans maybe harness a new approach to improve the sensitivity of tumors to radio-and chemotherapy.
