中国兽药杂志
中國獸藥雜誌
중국수약잡지
CHINESE JOURNAL OF VETERINARY DRUG
2011年
12期
31-34
,共4页
李智慧%黄山%孙文静%於娜
李智慧%黃山%孫文靜%於娜
리지혜%황산%손문정%어나
氟苯尼考%肠溶缓释%流化床%释放度
氟苯尼攷%腸溶緩釋%流化床%釋放度
불분니고%장용완석%류화상%석방도
florfenicol%sustained - released enteric - coated%fluidized bed%dissolution rate
采用湿法制粒、流化床包衣制备肠溶缓释微粒，正交法进行微粒处方、工艺参数的筛选，通过溶出度试验对其释放特性进行考察，筛选最佳工艺处方。在此优选处方和工艺条件下制得的微粒体外释放特性良好，在人工胃液中几乎不溶，而在人工肠液中释放达80％以上。本品处方合理，制备工艺简单，达到了肠溶缓释的目的，为氟苯尼考制剂的优化提供了依据。
採用濕法製粒、流化床包衣製備腸溶緩釋微粒，正交法進行微粒處方、工藝參數的篩選，通過溶齣度試驗對其釋放特性進行攷察，篩選最佳工藝處方。在此優選處方和工藝條件下製得的微粒體外釋放特性良好，在人工胃液中幾乎不溶，而在人工腸液中釋放達80％以上。本品處方閤理，製備工藝簡單，達到瞭腸溶緩釋的目的，為氟苯尼攷製劑的優化提供瞭依據。
채용습법제립、류화상포의제비장용완석미립，정교법진행미립처방、공예삼수적사선，통과용출도시험대기석방특성진행고찰，사선최가공예처방。재차우선처방화공예조건하제득적미립체외석방특성량호，재인공위액중궤호불용，이재인공장액중석방체80％이상。본품처방합리，제비공예간단，체도료장용완석적목적，위불분니고제제적우화제공료의거。
The sustained -released particles prepared by wet granulation were coated by fluidized bed. Orthogonal experiment design was used to optimize parameters of coating formulation and fluidized bed conditions, and the dissolution test was done to determine the release characteristics of particles. Results showed that there was little dissolved in the specified acidic stage and not less than 80% dissolved in the buffer stage. The design of the formula was reasonable with simple production technology and provided the basis for the pharmaceutical optimization.
