国际免疫学杂志
國際免疫學雜誌
국제면역학잡지
INTERNATIONAL JOURNAL OF IMMUNOLOGY
2010年
4期
269-272,331
,共5页
类风湿关节炎%骨破坏%破骨细胞%NF-κB受体激活剂配体%白介素17
類風濕關節炎%骨破壞%破骨細胞%NF-κB受體激活劑配體%白介素17
류풍습관절염%골파배%파골세포%NF-κB수체격활제배체%백개소17
Rheumatold artaritis%Bone destruction%Osteoclasts%RANKL%IL-17
破骨细胞是类风湿关节炎骨破坏机制研究的核心.NF-κB受体激活剂配体(RANKL)以及Th17细胞释放的白细胞介素(IL)-17与其分化及功能密切相关.破骨细胞(前体)内的受体、衔接子、激酶和转录因子在其融合、增殖与存活、细胞骨架重构和骨吸收等活动中起着至关重要作用.
破骨細胞是類風濕關節炎骨破壞機製研究的覈心.NF-κB受體激活劑配體(RANKL)以及Th17細胞釋放的白細胞介素(IL)-17與其分化及功能密切相關.破骨細胞(前體)內的受體、銜接子、激酶和轉錄因子在其融閤、增殖與存活、細胞骨架重構和骨吸收等活動中起著至關重要作用.
파골세포시류풍습관절염골파배궤제연구적핵심.NF-κB수체격활제배체(RANKL)이급Th17세포석방적백세포개소(IL)-17여기분화급공능밀절상관.파골세포(전체)내적수체、함접자、격매화전록인자재기융합、증식여존활、세포골가중구화골흡수등활동중기착지관중요작용.
Osteoclasts stand the core place of the researching on bone destruction of rheumatoid arthritis(RA).The latest hotspots-RANKL(receptor activator of NF-κB ligand)and interleukin-17(secreted by Th17)are tightly related to the differentiation and the function of osteoclasts.The receptors,adaptors,kinases and transcription factors in osteoclasts(precursors)are important to fusion,proliferation,survival,cytoskeleton remodeling,and bone resorption of osteoclasts(precursors).
