CAJ | 학술논문

钙离子(Ca2+)为肺动脉平滑肌细胞(PASMC)内至关重要的第二信史,其细胞内浓度的精细变化直接受到多种Ca2+通道的调控.按照细胞内Ca2+的来源,位于细胞膜上,调控细胞外Ca2+进入细胞的通道称为钙内流通道,位于肌质网上调控内质网/肌质网内钙库的Ca2+释放的通道称为钙释放通道.根据Ca2+通道激活方式的不同,Ca2+内流的通道主要分为电压依赖性Ca2+通道(VDCC)和非电压操纵性Ca2+通道(non VDCC).目前发现PASMC上表达的VDCC为CaV 1.2 L型通道,non-VDCC包括受体操纵性通道和钙库操纵性通道.PASMC 上的钙释放通道主要包括三磷酸肌醇受体系统和雷诺定受体系统.这些Ca2+通道通过对细胞内Ca2+的精细调节,使PASMC对各种信号刺激发生反应.
개리자(Ca2+)위폐동맥평활기세포(PASMC)내지관중요적제이신사,기세포내농도적정세변화직접수도다충Ca2+통도적조공.안조세포내Ca2+적래원,위우세포막상,조공세포외Ca2+진입세포적통도칭위개내류통도,위우기질망상조공내질망/기질망내개고적Ca2+석방적통도칭위개석방통도.근거Ca2+통도격활방식적불동,Ca2+내류적통도주요분위전압의뢰성Ca2+통도(VDCC)화비전압조종성Ca2+통도(non VDCC).목전발현PASMC상표체적VDCC위CaV 1.2 L형통도,non-VDCC포괄수체조종성통도화개고조종성통도.PASMC 상적개석방통도주요포괄삼린산기순수체계통화뢰낙정수체계통.저사Ca2+통도통과대세포내Ca2+적정세조절,사PASMC대각충신호자격발생반응.
Calcium ion (Ca2+ ) is an extremely crucial second messenger in the pulmonary artery smooth muscle cells (PASMC). The intracellular Ca2+ concentration is finely regulated by multiple Ca2+channels. According to the source of intraeellular Ca2+ , those lie in the cellular membrane and permit the extraeellular Ca2+ to enter into cytoplasm are named as calcium entry channels, and those lie in the sarcoplasmic reticulum and release the Ca2+ stored in it are called calcium release channels. According to pathway of activation, calcium entry channels are divided into voltage-operated Ca2+ channels (VOCC) and non-voltage-dependent Ca2+ channels (non-VOCC). The CaV 1.2 group or L-type VDCC, receptoroperated and store-operated non-VDCC have been found expressed in the PASMC. The calcium release channels mainly include inositol 1,4,5-trisphosphate receptor and Ryanodine receptor. Through the fine adjustment of all these Ca2+ channels, the PASMC react to various stimulus signals.