CAJ | 학술논문

目的探讨老年患者认知功能障碍与动脉僵硬度的关系.方法选择142例老年患者,以肢体动脉搏动波(PWV)作为评价动脉僵硬度指标,以简易精神状态量表(MMSE)作为认知功能评价指标,MMSE评分总分30分,评分<24分为认知功能障碍.对所有入选病例进行PWV检查及MMSE评分,根据MMSE评分将所有患者分为两组:认知功能正常组93例,认知功能障碍组49例.结果认知功能障碍组较认知功能正常组PWV明显增高[(13.3±2.4)m/s与(11.8±2.2)m/s,t=3.775,P-0.000].经Logistic回归分析,MMSE评分与PWV呈显著相关.结论动脉僵硬度增加是老年患者认知功能障碍重要危险因素.
목적 탐토노년환자인지공능장애여동맥강경도적관계.방법 선택142례노년환자,이지체동맥박동파(PWV)작위평개동맥강경도지표,이간역정신상태량표(MMSE)작위인지공능평개지표,MMSE평분총분30분,평분<24분위인지공능장애.대소유입선병례진행PWV검사급MMSE평분,근거MMSE평분장소유환자분위량조:인지공능정상조93례,인지공능장애조49례.결과 인지공능장애조교인지공능정상조PWV명현증고[(13.3±2.4)m/s여(11.8±2.2)m/s,t=3.775,P-0.000].경Logistic회귀분석,MMSE평분여PWV정현저상관.결론 동맥강경도증가시노년환자인지공능장애중요위험인소.
Objective To explore the relationship between cognitive impairment and arterial stiffness in elderly patients. Methods A total of 142 elderly patients were enrolled. Cognitive function was assessed by mini-mental state examination (MMSE) and arterial stiffness was assessed by pulse wave velocity (PWV). A full score on the MMSE was 30, and cognitive impairment was defined as a score less than 24. All subjects underwent the measurement of PWV and MMSE . The subjects were divided into 2 groups: 93 were assigned to the normal cognitive function group (MMSE score 24), and the remainders (n=49) were assigned to the cognitive impairment group (MMSE score 24). Results The PWV was significantly increased in the cognitive impairment group than in the normal cognitive function group [(13.3±2.4) m/s vs. (11.8±2.2) m/s, t=3. 775, P=0. 000]. Logistic regression analysis showed that the PWV was also independently and significantly associated with the MMSE score. Conclusions The increase of arterial stiffness is an important risk factor for impaired cognitive function in elderly patients.