中华临床感染病杂志
中華臨床感染病雜誌
중화림상감염병잡지
CHINESE JOURNAL OF CLINICAL INFECTIOUS DISEASES
2009年
4期
205-208
,共4页
肝炎%乙型%肝硬化%白细胞介素-10启动子%627位点%基因多态性
肝炎%乙型%肝硬化%白細胞介素-10啟動子%627位點%基因多態性
간염%을형%간경화%백세포개소-10계동자%627위점%기인다태성
Hepatitis B%Liver cirrhosis%Interleukin-10 promoter%Position 627%Gene polymorphism
目的 研究IL-10启动子区627位点多态性与乙型肝炎肝硬化的关系.方法 应用聚合酶链反应-限制性片段长度多态性(PCR-PFLP)等技术检测220例乙型肝炎肝硬化患者及200名健康对照者IL-10启动子627位等位基因及基因型频率的分布情况,分析其与肝硬化发病风险的相关性.结果 IL-10启动子627位点AA和CA基因型及等位基因A在乙型肝炎肝硬化中的分布明显高于对照组(X2=7.46、5.72和13.78,P值<0.01或0.05).结论 IL-10启动子627位点基因多态性与乙型肝炎肝硬化相关.
目的 研究IL-10啟動子區627位點多態性與乙型肝炎肝硬化的關繫.方法 應用聚閤酶鏈反應-限製性片段長度多態性(PCR-PFLP)等技術檢測220例乙型肝炎肝硬化患者及200名健康對照者IL-10啟動子627位等位基因及基因型頻率的分佈情況,分析其與肝硬化髮病風險的相關性.結果 IL-10啟動子627位點AA和CA基因型及等位基因A在乙型肝炎肝硬化中的分佈明顯高于對照組(X2=7.46、5.72和13.78,P值<0.01或0.05).結論 IL-10啟動子627位點基因多態性與乙型肝炎肝硬化相關.
목적 연구IL-10계동자구627위점다태성여을형간염간경화적관계.방법 응용취합매련반응-한제성편단장도다태성(PCR-PFLP)등기술검측220례을형간염간경화환자급200명건강대조자IL-10계동자627위등위기인급기인형빈솔적분포정황,분석기여간경화발병풍험적상관성.결과 IL-10계동자627위점AA화CA기인형급등위기인A재을형간염간경화중적분포명현고우대조조(X2=7.46、5.72화13.78,P치<0.01혹0.05).결론 IL-10계동자627위점기인다태성여을형간염간경화상관.
Objective To investigate the association between the polymorphism at position 627 in IL-10 promoter and the prevalence of HBV related cirrhosis. Methods PCR-restriction fragment length polymorphism (PCR-PFLP) was performed to detect polymorphisms of IL-10 promoter-627 in 220 patients with HBV related cirrhosis and 200 healthy controls. The contribution of polymorphism at position 627 to HBV related cirrhosis was calculated. Results The frequency of AA and CA genotypes and A allele at position 627 of IL-10 promoter region were significantly higher in patients with HBV-related cirrhosis than that of healthy controls (X2 = 7.46,5.72,13.78, P < 0.01 or P < 0.05 ). Conclusion There are significant association between the polymorphism at position 627 in the IL-10 promoter region and the prevalence of HBV related cirrhosis.
