CAJ | 학술논문

将81例哮喘重度发作婴幼儿按就诊顺序分为3组,分别采用布地奈德混悬液+硫酸沙丁胺醇雾化(布地奈德组,28例)、硫酸沙丁胺醇雾化+静脉用甲泼尼龙(甲泼尼龙组,34例)、硫酸沙丁胺醇雾化(硫酸沙丁胺醇组,19例)治疗,对其临床症状、血气变化进行比较.结果组内不同治疗时间患儿呼吸频率、心率、哮鸣音及自我感觉评分均随时间延长而逐渐降低,与治疗前比较差异有统计学意义(q=2.96～163.37,P＜0.05或0101);组间治疗后4 h时,硫酸沙丁胺醇组呼吸频率、心率明显高于布地奈德组(q=3.08、4.10,P＜0.05)和甲泼尼龙组(q=3.24、3.34,P＜0.05),治疗后4、12 h时哮鸣音、自我感觉评分硫酸沙丁胺醇组明显高于布地奈德组(q=5.63～23.63,P＜0.01)和甲泼尼龙组(q=6.76～23.72,P＜0.01).提示婴幼儿哮喘重度发作时,采用布地奈德混悬液吸入治疗可达到与静脉用甲泼尼龙基本相同的效果;单纯支气管扩张剂不能有效控制大多数婴幼儿重度哮喘的发作.
장81례효천중도발작영유인안취진순서분위3조,분별채용포지내덕혼현액+류산사정알순무화(포지내덕조,28례)、류산사정알순무화+정맥용갑발니룡(갑발니룡조,34례)、류산사정알순무화(류산사정알순조,19례)치료,대기림상증상、혈기변화진행비교.결과조내불동치료시간환인호흡빈솔、심솔、효명음급자아감각평분균수시간연장이축점강저,여치료전비교차이유통계학의의(q=2.96～163.37,P＜0.05혹0101);조간치료후4 h시,류산사정알순조호흡빈솔、심솔명현고우포지내덕조(q=3.08、4.10,P＜0.05)화갑발니룡조(q=3.24、3.34,P＜0.05),치료후4、12 h시효명음、자아감각평분류산사정알순조명현고우포지내덕조(q=5.63～23.63,P＜0.01)화갑발니룡조(q=6.76～23.72,P＜0.01).제시영유인효천중도발작시,채용포지내덕혼현액흡입치료가체도여정맥용갑발니룡기본상동적효과;단순지기관확장제불능유효공제대다수영유인중도효천적발작.
Eighty one infants with severe asthma attacks were randomly divided into three groups:budesonide group (budesonide suspension + ventolin inhalation),methylprednisolone group (Ventolin inhalation + intravenous methylprednisoloue) and ventolin group (ventolin inhalation alone).Compared with the pre-treatment,the respiratory rate,heart rate,wheeze score,self-feeling score of three groups were gradually reduced (q=2.96-163.37,P＜0.05 or 0.01).The respiratory rate,heart rate of ventolin group was significantly higher than those of budesonide group (q=3.08,4.10,P＜0.05) and methylprednisolone group (q=3.24,3.34,P＜0.05) 4 h after treatment,wheeze score,self-feeling score of ventolin group was significantly higher than budesonide group (q=5.63-23.63,P＜0.01) and methylprednisolone group (q=6.76-23.72,P＜0.01) 4 and 12 h after treatment.Results indicate that budesonide suspension can achieve the same effect as intravenous methylprednisolone and bronchodilators alone may not effectively control the severe asthma attack in infants.