CAJ | 학술논문

以正常对照、垂体全切除和新鲜新生兔脑垂体移植组为参照,探讨了冻存再植垂体的内分泌功能重建.结果表明冻存再植垂体体内存活,并有分泌功能.环孢素A(CsA)的服用对新鲜垂体移植组作用显著,但在冻存垂体移植组无显著效应,提示冷冻保存改变了移植物的免疫原性.
이정상대조、수체전절제화신선신생토뇌수체이식조위삼조,탐토료동존재식수체적내분비공능중건.결과표명동존재식수체체내존활,병유분비공능.배포소A(CsA)적복용대신선수체이식조작용현저,단재동존수체이식조무현저효응,제시냉동보존개변료이식물적면역원성.
Cryopreserved neonatal pituitary transplantation were carried out in two kinds of rabbits with different MHC The pituitary grafts were transplanted underneath the median eminence of the recipients after hypophysectomy. Blood samples of rabbits in every group were taken at regular intervals for the determinations of serum thyroxin, prolacin, luteinizing hormone and growth hormone. The results showed that cryopreserved neonatal pituitary grafts could survive and function well with or without CsA. It was suggested that cryopreservation method might reduce the immunogenicity of the graft. The results also disclosed that the interrelationship between the pituitary graft and the host's hypothalamus could be established.