中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2010年
13期
37-38
,共2页
李淑丽%孙和才%吴汝霞%马会玲
李淑麗%孫和纔%吳汝霞%馬會玲
리숙려%손화재%오여하%마회령
新生儿%缺血缺氧性脑病%脑利钠肽
新生兒%缺血缺氧性腦病%腦利鈉肽
신생인%결혈결양성뇌병%뇌리납태
Newborn%Hypoxic-ischemic encephalopathy%Brain natriuretic peptide
目的 研究新生儿缺血缺氧性脑病(HIE)患儿血浆脑利钠肽(BNP)水平的变化,探讨血浆BNP水平与新生儿HIE严重程度之间的关系. 方法 采用放射免疫法测定54例HIE患儿血浆BNP水平,并与22例对照组患儿比较.结果 中、重度HIE患儿急性期血浆BNP水平分别为(896±358)、(1043±590) ng/L,明显高于对照组(234±60) ng/L和轻度组(334±38) ng/L(P<0.01);中、重度HIE患儿恢复期血浆BNP水平分别为(346±50)、(432±90) ng/L明显低于急性期水平;但中、重度HIE患儿中7例有神经系统后遗症者在恢复期(14 d)血浆BNP水平为(823±298) ng/L明显高于预后良好的30例(336±42) ng/L(P<0.01),且持续到6个月. 结论 新生儿HIE患儿血浆BNP水平的变化与HIE的严重程度密切相关.
目的 研究新生兒缺血缺氧性腦病(HIE)患兒血漿腦利鈉肽(BNP)水平的變化,探討血漿BNP水平與新生兒HIE嚴重程度之間的關繫. 方法 採用放射免疫法測定54例HIE患兒血漿BNP水平,併與22例對照組患兒比較.結果 中、重度HIE患兒急性期血漿BNP水平分彆為(896±358)、(1043±590) ng/L,明顯高于對照組(234±60) ng/L和輕度組(334±38) ng/L(P<0.01);中、重度HIE患兒恢複期血漿BNP水平分彆為(346±50)、(432±90) ng/L明顯低于急性期水平;但中、重度HIE患兒中7例有神經繫統後遺癥者在恢複期(14 d)血漿BNP水平為(823±298) ng/L明顯高于預後良好的30例(336±42) ng/L(P<0.01),且持續到6箇月. 結論 新生兒HIE患兒血漿BNP水平的變化與HIE的嚴重程度密切相關.
목적 연구신생인결혈결양성뇌병(HIE)환인혈장뇌리납태(BNP)수평적변화,탐토혈장BNP수평여신생인HIE엄중정도지간적관계. 방법 채용방사면역법측정54례HIE환인혈장BNP수평,병여22례대조조환인비교.결과 중、중도HIE환인급성기혈장BNP수평분별위(896±358)、(1043±590) ng/L,명현고우대조조(234±60) ng/L화경도조(334±38) ng/L(P<0.01);중、중도HIE환인회복기혈장BNP수평분별위(346±50)、(432±90) ng/L명현저우급성기수평;단중、중도HIE환인중7례유신경계통후유증자재회복기(14 d)혈장BNP수평위(823±298) ng/L명현고우예후량호적30례(336±42) ng/L(P<0.01),차지속도6개월. 결론 신생인HIE환인혈장BNP수평적변화여HIE적엄중정도밀절상관.
Objective To study the change of BNP(Brain natriuretic peptide) in plasma of the children diagnosed with newborn Hypoxic-ischemic encephalopathy (HIE) and discuss the relationship between the level of BNP in plasma and the severity of HIE. Methods Testing the level of BNP of 54 children with HIE by radioimmunoassay (RIA) and comparing to 22 children in control Group. Results The level of BNP of children with moderate HIE in the acute period was (896±358)ng/L and the severe one was (1043±590)ng/L.In the recovery period, the moderate one was(346±50)ng/L and the severe one was (432±90)ng/L, which were obviously lower than the acute level. However, in the recovery period there were 7 cases with nervous system sequelae whose level was (823±298)ng/L, which was much higher than the 30 cases well recovered with the level (336.2±42)(P<0.01),lasting 6 months. Conclusions The level of BNP in plasma of children with newborn HIE is related with the severity of HIE.
