CAJ | 학술논문

近年来阿尔茨海默病(AD)已被学术界称为"3型糖尿病",这是由于AD具有和糖尿病相似的发病机制,即大脑胰岛素缺乏和胰岛素抵抗.糖尿病通过"肝-脑轴"将外周胰岛素抵抗向中枢"传递",从而促进认知功能障碍的发生,是AD重要的危险因素,而这种"传递"作用甚至可能在糖尿病前期--葡萄糖调节受损状态就已经存在.在认知功能障碍的防治上,改善胰岛素抵抗成为新的研究方向.
근년래아이자해묵병(AD)이피학술계칭위"3형당뇨병",저시유우AD구유화당뇨병상사적발병궤제,즉대뇌이도소결핍화이도소저항.당뇨병통과"간-뇌축"장외주이도소저항향중추"전체",종이촉진인지공능장애적발생,시AD중요적위험인소,이저충"전체"작용심지가능재당뇨병전기--포도당조절수손상태취이경존재.재인지공능장애적방치상,개선이도소저항성위신적연구방향.
In recent years, Alzheimer's disease has represented "type 3 diabetes mellitus (T3DM)".T3DM corresponds to brain insulin deficiency and insulin resistance that is similar to the pathogenesis of diabetes. Diabetes mellitus may "transmit" insulin resistance from peripheral tissue to central nervous system via a"liver-brain axis" to promote the development of cognitive impairment. Thus diabetes is an important risk factor of Alzheimer's disease. And it is likely that the function of "transmission" has existed at the stage of pre-diabetes--impaired glucose regulation. The strategy of improving insulin resistance has provided a new direction to prevent and cure cognitive impairment.