CAJ | 학술논문

目的分析影响血液病患者首次血小板输注疗效的因素.方法观察87例血液病患者输注机采血小板的疗效,所有患者均输入血小板10U(血小板数≥2.5×1011个),观察输注后血小板计数纠正增加指数( CCI),分析病种、脾大、发热、年龄、性别对血小板首次输注有效率的影响.结果血小板输注有效病例为66例(有效率75.9％),血小板输注有效率再生障碍性贫血(AA)为80.0％、特发性血小板减少性紫癜(ITP)为78.1％、急性白血病(AL)为65.2％、骨髓增生异常综合征(MDS)为82.3％,不同病种有效率差异无统计学意义(x2=2.88,P＞0.05).发热感染者(31例)有效率为58.1％,明显低于无发热感染者(56例)的85.7％(x 2=8.3308,P＜0.01)；脾不大者(59例)有效率为86.4％,明显高于脾大者(28例)的53.6％(x 2=11.2033,P＜ 0.01)；男性、女性有效率分别为76.0％、75.7％,差异无统计学意义(x2=0.0012,P＞0.05)；＜60周岁者与≥60周岁者有效率分别为74.5％、77.8％,差异无统计学意义(x2=0.1231,P＞0.05).结论发热及脾大是影响血液病患者首次血小板输注疗效的因素.
목적 분석영향혈액병환자수차혈소판수주료효적인소.방법 관찰87례혈액병환자수주궤채혈소판적료효,소유환자균수입혈소판10U(혈소판수≥2.5×1011개),관찰수주후혈소판계수규정증가지수( CCI),분석병충、비대、발열、년령、성별대혈소판수차수주유효솔적영향.결과 혈소판수주유효병례위66례(유효솔75.9％),혈소판수주유효솔재생장애성빈혈(AA)위80.0％、특발성혈소판감소성자전(ITP)위78.1％、급성백혈병(AL)위65.2％、골수증생이상종합정(MDS)위82.3％,불동병충유효솔차이무통계학의의(x2=2.88,P＞0.05).발열감염자(31례)유효솔위58.1％,명현저우무발열감염자(56례)적85.7％(x 2=8.3308,P＜0.01)；비불대자(59례)유효솔위86.4％,명현고우비대자(28례)적53.6％(x 2=11.2033,P＜ 0.01)；남성、녀성유효솔분별위76.0％、75.7％,차이무통계학의의(x2=0.0012,P＞0.05)；＜60주세자여≥60주세자유효솔분별위74.5％、77.8％,차이무통계학의의(x2=0.1231,P＞0.05).결론 발열급비대시영향혈액병환자수차혈소판수주료효적인소.
Objective To study the efficiency of the first time platelet transfusion in patients with blood diseases.Methods Investigate the effect of platelet transfusion in 87 patients with blood diseases.All the patients were transfused 10U platelet (platelet≥2.5×1011 ).Observe CCI after platelet transfusion and analyse the influence factors to the efficiency of the first time platelet transfusion such as the kind of diseases,splenomegaly,fever,age and sex.Results After platelet transfusion,66 patients (75.9 ％) were effective.The efficancy rates were 80.0 ％,78.1％,65.2 ％,82.3 ％ in AA,ITP,AL,MDS (x2=2.88,P＞0.05).In 31 patients with a fever and infaction the efficancy rate was 58.1％,but it was 85.7％ in 56 patients without a fever and infaction (x2=8.3308,P＜0.01).The efficancy rate in 59 patients with non-splenomegaly was 86.4 ％.It was higher than that in 28 patients with splenomegaly which was 53.6％(x2=11.2033,P＜0.01).The efficancy rate was 76.0％ in male patients and it was 75.7 ％ in female patients (x2=- 0.0012,P＞0.05).The efficancy rate was 74.5 ％ in young group (＜60 years old)and 77.8 ％ in old group (≥60 years old)(x2=0.1231,P＞0.05).Conclusion Fever and splenomegaly are the influence factors to the efficiency of the first time platelet transfusion.