中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2012年
11期
1634-1636
,共3页
癌,非小细胞肺%免疫组织化学%受体,表皮生长因子%血管内皮生长因子类
癌,非小細胞肺%免疫組織化學%受體,錶皮生長因子%血管內皮生長因子類
암,비소세포폐%면역조직화학%수체,표피생장인자%혈관내피생장인자류
Cancer,non-small cell lung%Immunohistochemistry%Receptor,epidermal growth factor%Vascular endothelial growth factors
目的 观察非小细胞肺癌(NSCLC)组织中表皮生长因子受体(EGFR)和血管内皮生长因子(VEGF)的表达情况以及与临床病理特征的关系.方法 采用免疫组化法检测124例NSCLC组织和15例远离肿块无癌细胞浸润的肺组织(距肿瘤病变＞5 cm)标本EGFR、VEGF的表达.结果 EGFR、VEGF在124例NSCLC标本中的阳性表达率分别为52.4％、66.1％,在15例远离肿块无癌细胞浸润的肺组织(距肿瘤病变＞5 cm)均无表达.Ⅲ期NSCLC组织的VEGF表达率为80.4％ (41/51),高于Ⅰ-Ⅱ期的56.2％ (41/73)(x2=4.24,P＜0.05)；淋巴结阳性的NSCLC组织VEGF表达率为78.2％ (50/64),明显高于淋巴结阴性的53.3％(32/60)(x2=4.77,P＜0.05),VEGF和EGFR表达与病理类型、性别、年龄、肿瘤细胞分化等无关.EGFR与VEGF呈正相关关系(r=0.93,P＜0.05).结论 EGFR、VEGF在NSCLC组织中过表达；VEGF可能与TNM分期及淋巴结转移有关,EGFR与VEGF在NSCLC肿瘤血管形成过程中可能起协同作用.
目的 觀察非小細胞肺癌(NSCLC)組織中錶皮生長因子受體(EGFR)和血管內皮生長因子(VEGF)的錶達情況以及與臨床病理特徵的關繫.方法 採用免疫組化法檢測124例NSCLC組織和15例遠離腫塊無癌細胞浸潤的肺組織(距腫瘤病變＞5 cm)標本EGFR、VEGF的錶達.結果 EGFR、VEGF在124例NSCLC標本中的暘性錶達率分彆為52.4％、66.1％,在15例遠離腫塊無癌細胞浸潤的肺組織(距腫瘤病變＞5 cm)均無錶達.Ⅲ期NSCLC組織的VEGF錶達率為80.4％ (41/51),高于Ⅰ-Ⅱ期的56.2％ (41/73)(x2=4.24,P＜0.05)；淋巴結暘性的NSCLC組織VEGF錶達率為78.2％ (50/64),明顯高于淋巴結陰性的53.3％(32/60)(x2=4.77,P＜0.05),VEGF和EGFR錶達與病理類型、性彆、年齡、腫瘤細胞分化等無關.EGFR與VEGF呈正相關關繫(r=0.93,P＜0.05).結論 EGFR、VEGF在NSCLC組織中過錶達；VEGF可能與TNM分期及淋巴結轉移有關,EGFR與VEGF在NSCLC腫瘤血管形成過程中可能起協同作用.
목적 관찰비소세포폐암(NSCLC)조직중표피생장인자수체(EGFR)화혈관내피생장인자(VEGF)적표체정황이급여림상병리특정적관계.방법 채용면역조화법검측124례NSCLC조직화15례원리종괴무암세포침윤적폐조직(거종류병변＞5 cm)표본EGFR、VEGF적표체.결과 EGFR、VEGF재124례NSCLC표본중적양성표체솔분별위52.4％、66.1％,재15례원리종괴무암세포침윤적폐조직(거종류병변＞5 cm)균무표체.Ⅲ기NSCLC조직적VEGF표체솔위80.4％ (41/51),고우Ⅰ-Ⅱ기적56.2％ (41/73)(x2=4.24,P＜0.05)；림파결양성적NSCLC조직VEGF표체솔위78.2％ (50/64),명현고우림파결음성적53.3％(32/60)(x2=4.77,P＜0.05),VEGF화EGFR표체여병리류형、성별、년령、종류세포분화등무관.EGFR여VEGF정정상관관계(r=0.93,P＜0.05).결론 EGFR、VEGF재NSCLC조직중과표체；VEGF가능여TNM분기급림파결전이유관,EGFR여VEGF재NSCLC종류혈관형성과정중가능기협동작용.
Objective To observe the expression of epidermal growth factor receptor(EGFR) and vascular endothelial growth factor(VEGF) in non-small cell lung cancer(NSCLC) and the reletionship with clinic-pathologic parameters.Methods Immunohistochemistry of tissue sections was used to study the expression of EGFR and VEGF in 124 NSCLC tissues and 15 normal lung tissues adjacent to cancer tissues.Results The positive rates of EGFR and VEGF in 124 NSCLC samples were 52.4％,66.1％,while no expressed in the 15 normal lung tissues adjacent to cancer tissues.The positive rate of VEGF with stage Ⅲ was higher than that with stage Ⅰ - Ⅱ ( 80.4％ vs 56.2％,P ＜0.05).The positive rate of VEGF with lymph node metastasis was higher than that without lymph node metastasis (78,2％ vs 53.3％,P ＜ 0.05 ).The expression of VEGF and EGFR had no relationship with clinic pathological factors including histological type of lung cancer,sex,age.EGFR and VEGF expression was statistically correlated with each other( r =0.93,P ＜0.05 ).Conclusion EGFR and VEGF were overexpressed in NSCLC tissues.The expression of VEGF was correlated with TNM stages and lymph node metastasis.The expression of EGFR was correlated with VEGF expression in NSCLC tissues,which indicates they might act synergistically in angiogenesis of NSCLC.
