CAJ | 학술논문

甲状旁腺激素基因多态性与广东地区汉族女性骨密度的关系
갑상방선격소기인다태성여엄동지구한족녀성골밀도적관계
The Relationship between Polymorphisms of parathyroid hormone Gene and Bone Mineral Density of Han Nationality Women in Guangdong Area

万方数据

广东医学廣東醫學 엄동의학
GUNAGDONG MEDICAL JOURNAL
2010年 2期 173-176 ,共4页

何斌%李东风%吴文%黄小穗%杨燕红%林凯%邓海鸥%智喜梅%蔡雪珍%荣卡彬%蒋文玲%王瑞雪%董婷

하빈%리동풍%오문%황소수%양연홍%림개%산해구%지희매%채설진%영잡빈%장문령%왕서설%동정

骨密度%甲状旁腺素%基因多态性骨密度%甲狀徬腺素%基因多態性
골밀도%갑상방선소%기인다태성
bone mineral density%parathyroid hormone%gene polymorphisms

目的探讨甲状旁腺素(parathyroid hormone,PTH)基因多态性与广东地区部分汉族女性人群骨密度(bone mineral density,BMD)的相关性.方法选取广东成年女性617例,年龄30～75岁,平均(47.82±13.57)岁,用聚合酶链反应及限制性片段长度多态性技术检测外周血白细胞基因组护骨素基因型,采用双能X线吸收测定其腰椎侧位、股骨颈、粗隆间、大转子、ward's三角等部位的骨密度值.结果 617例受试对象中,PTH基因BB型447例(72.4%);Bb型157例(25.4%);和bb型13例(2.1%).绝经前妇女PTH基因多态性频率与绝经后妇女比较差异无统计学意义.无论是整个受试群体,还是将其分为绝经前及绝经后群体,其基因及基因型分布均符合Hardy-Wenbeng平衡定律.经协方差分析校正了年龄、体质指数等因素后(对绝经后妇女人群,同时对绝经年限进行校正)发现,3种不同的基因型相互之间的BMD变化均差异无统计学意义(P>0.05).结论 PTH基因多态性与广东地区汉族妇女人群BMD关系不密切,不能作为筛查和预示骨质疏松症的遗传易感位点.
목적 탐토갑상방선소(parathyroid hormone,PTH)기인다태성여엄동지구부분한족녀성인군골밀도(bone mineral density,BMD)적상관성.방법 선취엄동성년녀성617례,년령30～75세,평균(47.82±13.57)세,용취합매련반응급한제성편단장도다태성기술검측외주혈백세포기인조호골소기인형,채용쌍능X선흡수측정기요추측위、고골경、조륭간、대전자、ward's삼각등부위적골밀도치.결과 617례수시대상중,PTH기인BB형447례(72.4%);Bb형157례(25.4%);화bb형13례(2.1%).절경전부녀PTH기인다태성빈솔여절경후부녀비교차이무통계학의의.무론시정개수시군체,환시장기분위절경전급절경후군체,기기인급기인형분포균부합Hardy-Wenbeng평형정률.경협방차분석교정료년령、체질지수등인소후(대절경후부녀인군,동시대절경년한진행교정)발현,3충불동적기인형상호지간적BMD변화균차이무통계학의의(P>0.05).결론 PTH기인다태성여엄동지구한족부녀인군BMD관계불밀절,불능작위사사화예시골질소송증적유전역감위점.
Objective To Investigate distribution of frequency of parathyroid hormone (PTH) gene polymorphisms in Han Nationality women in Guangdong area and the relationship between PTH phenotypes and bone mineral density (BMD) in young and postmenopausal women. Methods Polymorphism of PTH gene was detected by polymerase chain reaction-restriction fragment length polymorphism ( PCR-RELP) in 617 subjects selected from Han nationality women in Guangzhou area (aged 30～75 years, 47.82±13.57). BMD was measured by dual-energy X-ray absorptionmetry (DEXA) in Lumbar vertebrae, neck of femur, intertrochanteric ridge, trochanter major and Ward's triangle area. Results PTH genotype frequencies of BB,Bb and bb were 72.4%, 25.4% and 2.1%, respectively. There was no significant difference in genotypes frequencies between young and postmenopausal women. Furthermore, the frequencies distribution of BstBI alleles followed the Hardy-Weinberg equilibrium. There was no significant difference in the mean BMD among these genotype groups (p>0.05 by analysis of Covariance).Conclusion PTH gene polymorphisms is not associated with BMD in Han Nationality women in Guangzhou.