CAJ | 학술논문

脂肪组织是一个重要的内分泌器官.肥大的脂肪细胞分泌过量脂肪细胞因子,促进了胰岛素抵抗和糖尿病的发生、发展.视黄醇结合蛋白4(RBP4)主要由肝脏合成,负责维生素A的转运.新近研究发现,RBP4是一个新的脂肪细胞因子,与胰岛素抵抗相关疾病、体脂分布和糖尿病均有密切联系,它的发现为明确胰岛素抵抗发生机制提供了新的论据.
지방조직시일개중요적내분비기관.비대적지방세포분비과량지방세포인자,촉진료이도소저항화당뇨병적발생、발전.시황순결합단백4(RBP4)주요유간장합성,부책유생소A적전운.신근연구발현,RBP4시일개신적지방세포인자,여이도소저항상관질병、체지분포화당뇨병균유밀절련계,타적발현위명학이도소저항발생궤제제공료신적론거.
Adipose tissue is an important endocrine organ.Enlarged adipocytes produce excess adipocytokines,which promote the development of insulin resistance and diabetes.Retinol binding protein 4 (RBP4)is mainly produced by liver and plays an important role in transportation of vitamin A.Recent studies have shown that RBP4 is a new adipocytokine associated with insulin resistance related diseases,fat distribution,and diabetes.The discovery of RBP4 provides new evidents for illuminating the mechanism of insulin resistance.