国际中医中药杂志
國際中醫中藥雜誌
국제중의중약잡지
INTERNATIONAL JOURNAL OF TRIDITIONAL CHINESE MEDICINE
2011年
12期
1064-1068
,共5页
尹倚艰%冯玲%路杰%李薇
尹倚艱%馮玲%路傑%李薇
윤의간%풍령%로걸%리미
血脂代谢异常%祛湿化浊通心方
血脂代謝異常%祛濕化濁通心方
혈지대사이상%거습화탁통심방
Abnormal metabolism of lipid%Dampness-removing,turbid-resolving and heart-commuuicating formula
目的 观察路志正教授祛湿化浊通心方干预老年血脂代谢异常的疗效及安全性.方法 采用随机数字表法将60例老年血脂代谢异常患者随机分为两组各30例,治疗组给予祛湿化浊通心方治疗,1剂/d,分2次温水冲服；对照组口服绞股蓝总苷片,60 mg/次,3次/d,餐前服用.两组患者均治疗4周为1个疗程,2个疗程后统计疗效.结果 治疗组治疗后除高密度脂蛋白(HDL-C)外,总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)均较治疗前明显改善[分别为(5.81±1.70) mmol/L、(3.05±2.30) mmol/L、(3.39±1.11) mmol/L,P＜0.01或0.05],并低于对照组[分别为(6.16±1.91) mmol/L、(3.03±1.89) mmol/L、(3.81±0.63) mmol/L,P＜0.01或0.05].治疗组LDL-C达标情况,以及对胸闷、头昏、头重如裹、头痛、口黏不渴、大便不爽、恶心呕吐、肢体沉重等中医证候疗效优于对照组(平均秩分别为23.83、38.10、36.10、34.70、36.77、39.82、33.38、34.17)；治疗组在血、尿、便常规、心电图、ALT、AST、Cr等安全性指标方面未见异常.结论 祛湿化浊通心方可明显改善血脂代谢异常患者的临床症状及体征,有效调节血脂异常,疗效优于绞股蓝总苷片.
目的 觀察路誌正教授祛濕化濁通心方榦預老年血脂代謝異常的療效及安全性.方法 採用隨機數字錶法將60例老年血脂代謝異常患者隨機分為兩組各30例,治療組給予祛濕化濁通心方治療,1劑/d,分2次溫水遲服；對照組口服絞股藍總苷片,60 mg/次,3次/d,餐前服用.兩組患者均治療4週為1箇療程,2箇療程後統計療效.結果 治療組治療後除高密度脂蛋白(HDL-C)外,總膽固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)均較治療前明顯改善[分彆為(5.81±1.70) mmol/L、(3.05±2.30) mmol/L、(3.39±1.11) mmol/L,P＜0.01或0.05],併低于對照組[分彆為(6.16±1.91) mmol/L、(3.03±1.89) mmol/L、(3.81±0.63) mmol/L,P＜0.01或0.05].治療組LDL-C達標情況,以及對胸悶、頭昏、頭重如裹、頭痛、口黏不渴、大便不爽、噁心嘔吐、肢體沉重等中醫證候療效優于對照組(平均秩分彆為23.83、38.10、36.10、34.70、36.77、39.82、33.38、34.17)；治療組在血、尿、便常規、心電圖、ALT、AST、Cr等安全性指標方麵未見異常.結論 祛濕化濁通心方可明顯改善血脂代謝異常患者的臨床癥狀及體徵,有效調節血脂異常,療效優于絞股藍總苷片.
목적 관찰로지정교수거습화탁통심방간예노년혈지대사이상적료효급안전성.방법 채용수궤수자표법장60례노년혈지대사이상환자수궤분위량조각30례,치료조급여거습화탁통심방치료,1제/d,분2차온수충복；대조조구복교고람총감편,60 mg/차,3차/d,찬전복용.량조환자균치료4주위1개료정,2개료정후통계료효.결과 치료조치료후제고밀도지단백(HDL-C)외,총담고순(TC)、감유삼지(TG)、저밀도지단백(LDL-C)균교치료전명현개선[분별위(5.81±1.70) mmol/L、(3.05±2.30) mmol/L、(3.39±1.11) mmol/L,P＜0.01혹0.05],병저우대조조[분별위(6.16±1.91) mmol/L、(3.03±1.89) mmol/L、(3.81±0.63) mmol/L,P＜0.01혹0.05].치료조LDL-C체표정황,이급대흉민、두혼、두중여과、두통、구점불갈、대편불상、악심구토、지체침중등중의증후료효우우대조조(평균질분별위23.83、38.10、36.10、34.70、36.77、39.82、33.38、34.17)；치료조재혈、뇨、편상규、심전도、ALT、AST、Cr등안전성지표방면미견이상.결론 거습화탁통심방가명현개선혈지대사이상환자적림상증상급체정,유효조절혈지이상,료효우우교고람총감편.
Objective To observe the effect and safety of treating senile abnormal lipid metabolism with LU Zhi-zheng's dampness-removing,turbid-resolving and heart-communicating formula.Methods 60 patients were randomly divided into a treatment,treated with LU's formula,one dosage per day,and a control group,treated with gypenosides,60mg/tablet,three times per day,with 30 patients in each group.Both groups were treated two therapeutic courses,which were 8 weeks.Results Except HDL-C,other indexes including TC,TG,LDL-C in the treatment group were all obviously improved after the treatment [the statistical values were (5.81 ± 1.70) mmol/L,(3.05±2.30) mmol/L,(3.39± 1.11 ) mmol/L respectively,P＜0.01 or 0.05],which were also better than the control group [the statistical values were ( 6.16 ± 1.91 ) mmol/L,( 3.03 ± 1.89 ) mmol/L,(3.81±0.63) mmol/L,P＜0.01 or 0.05].Symptoms improvement such as chest oppression,dizziness,heaviness of head,headache,sticky mouth without thirsty,constipation,nausea and vomiting,and heaviness of limbs in the treatment group were also better than the control group,with mean rank were 23.83、38.10、36.10、34.70、36.77、39.82、33.38、34.17 respectively.No abnormal changes were found in indexes of blood routine,urinary routine,stool routine,ECG,ALT,AST and Cr.Conclusion LU Zhi-zheng's dampness-removing,turbid-resolving and heart-communicating formula improved clinical symptoms and signs of abnormal lipid metabolism patients,its therapeutic effects were better than gypenosides.
