CAJ | 학술논문

目的:合成新型的两亲性小分子,并通过新的自组装方法制备其纳米材料.方法:用胆固醇对氨基匍萄糖进行疏水改性,使其具有两亲性;用核磁和红外表征目标产物N-胆固醇基琥珀酰基氨基葡萄糖(CSG)的化学结构,结合纳米共沉淀法和超声分散法制备其自组装体,并用扫描电镜、圆二色谱考察其自组装体的性质.结果:CSG通过这种新的方法形成具有高轴向比的纳米纤维状自组装体,分子在自组装过程中采取手性排列的方式.结论:通过设计分子的化学结构、控制自组装的方法和条件,可以得到先进的纳米材料.
목적:합성신형적량친성소분자,병통과신적자조장방법제비기납미재료.방법:용담고순대안기포도당진행소수개성,사기구유량친성;용핵자화홍외표정목표산물N-담고순기호박선기안기포도당(CSG)적화학결구,결합납미공침정법화초성분산법제비기자조장체,병용소묘전경、원이색보고찰기자조장체적성질.결과:CSG통과저충신적방법형성구유고축향비적납미섬유상자조장체,분자재자조장과정중채취수성배렬적방식.결론:통과설계분자적화학결구、공제자조장적방법화조건,가이득도선진적납미재료.
Objective To synthesize a new type of amphiphile and prepare its nano-materials through a new self-assembly method. Methods New type of amphiphile was synthesized by linking the cholesterol group as the hydrophobic group to a glucasamine moiety. The structures of the products were characterized by infrared rediation(IR) and nuclear magnetic resonance spectrometry(1H-NMR). A simple nanoprecipitation method and probe sonication method were adopted to prepare the N-cholesteryl succinyl glucosamine(CSG) self-assemblies.The self-assembly properties were investigated by SEM and CD. Results CSG exhibited a fibrous structure with high length-to-width ratio. CSG adopted the helical arrangement in the aggregation. Conclusion Novel nano-materials could be prepared by designing the structures of amphiphiles and controlling the self-assembly methods and conditions.