CAJ | 학술논문

经典的内分泌腺通过神经系统、激素、细胞因子、生长因子与其他器官进行广泛的联系.Toll样受体(TLRs)在多种内分泌细胞和免疫细胞中表达,其研究日益受到关注.TLRs的持续高度激活可导致相应内分泌代谢性疾病的发生,其中TLR-2和TLR4的缺陷导致小鼠在类似全身炎性反应综合征(SIRS)条件下,发生肾上腺皮质应激应答功能障碍;TLR-3在甲状腺疾病的发病机制中发挥特殊作用.TLRs信号途径的激活伴有特定细胞因子和趋化因子的上调,可导致内分泌腺肿瘤的发生;而在胰岛中表达的TLRs增加了胰岛对病毒感染的易感性.
경전적내분비선통과신경계통、격소、세포인자、생장인자여기타기관진행엄범적련계.Toll양수체(TLRs)재다충내분비세포화면역세포중표체,기연구일익수도관주.TLRs적지속고도격활가도치상응내분비대사성질병적발생,기중TLR-2화TLR4적결함도치소서재유사전신염성반응종합정(SIRS)조건하,발생신상선피질응격응답공능장애;TLR-3재갑상선질병적발병궤제중발휘특수작용.TLRs신호도경적격활반유특정세포인자화추화인자적상조,가도치내분비선종류적발생;이재이도중표체적TLRs증가료이도대병독감염적역감성.
Endocrine glands link with other tissues via nervous system, hormone, cytokines and growth factors. The expression of Toll-like receptors (TLRs) has been found in several endocrine and immune cells within endocrine glands. Close attention has been paid on its research. However, excessive activation of these receptors contributes to several endocrine and metabolic diseases. TLR-2 and TLR-4 deficiency results in impaired adrenal corticosterone stress response in mice under systemic inflammatory response syndrome-like conditions(SlRS). TLR-3 plays a specific role in thyroid pathophysiology. Activation of TLRs signaling pathways is associated with upregulation of certain cytokines and chemokines, it may contribute to tumorigene-sis. The expression of TLRs in normal pancreatic islets makes islets sensitive to viral infection.