CAJ | 학술논문

目的对内毒素检测阳性的肺结核患者实施不同治疗策略,分析不同策略的成本-效果,为利用一清胶囊治疗革兰阴性菌(G)感染提供理论和经济学依据.方法 120例内毒素检测阳性的肺结核患者随机分为治疗组和对照组,治疗组同时接受一清胶囊联合常规的抗菌治疗,对照组仅进行常规的抗菌治疗.分别记录患者的CRP的复常时间、体温复常时间、内毒素转阴时间以及影像的感染情况改善程度进行成本-效果分析.结果治疗组的CRP复常时间、体温复常时间和内毒素转阴时间均明显短于对照组.两组患者均未观察到空洞闭合,但治疗组47例患者的结核病灶有吸收好转(有效率78.3％)；对照组33例患者的结核病灶有吸收好转(有效率55.0％),两组比较差异有统计学意义(x2=4.97,P＜0.05).成本-效果分析表明对照组疗效较差且治疗成本明显偏高(P=0.013).结论一清胶囊与常规抗菌治疗之间具有协同作用,能明显缩短病程和住院时间,两者联用成本效果更好,具有重要的经济价值.
목적 대내독소검측양성적폐결핵환자실시불동치료책략,분석불동책략적성본-효과,위이용일청효낭치료혁란음성균(G)감염제공이론화경제학의거.방법 120례내독소검측양성적폐결핵환자수궤분위치료조화대조조,치료조동시접수일청효낭연합상규적항균치료,대조조부진행상규적항균치료.분별기록환자적CRP적복상시간、체온복상시간、내독소전음시간이급영상적감염정황개선정도진행성본-효과분석.결과 치료조적CRP복상시간、체온복상시간화내독소전음시간균명현단우대조조.량조환자균미관찰도공동폐합,단치료조47례환자적결핵병조유흡수호전(유효솔78.3％)；대조조33례환자적결핵병조유흡수호전(유효솔55.0％),량조비교차이유통계학의의(x2=4.97,P＜0.05).성본-효과분석표명대조조료효교차차치료성본명현편고(P=0.013).결론 일청효낭여상규항균치료지간구유협동작용,능명현축단병정화주원시간,량자련용성본효과경호,구유중요적경제개치.
Objective To evaluate the cost-effectiveness of different strategies for treating tuberculosis patients co-infected with Gram-negative bacillus,to provide the theoretical and economic evidences for the use of Yiqing Capsule.Methods 120 tuberculosis patients with endotoxin testing positive were randomly divided into therapy group and control group.Both groups were given antituberculosi treatment and antibacterial agents,patients in treatment group were given Yiqing capsule additionally.The days until temperature normalized,levels of CRP normalized and concentration of endotoxin normalized were collected and the cost-effectiveness were conducted,improvements on images were also compared between the groups.Results The days until temperature normalized,levels of CRP normalized and concentration of endotoxin normalized in therapy group were shorter than control group (P ＜0.05).No empty closed after treatment in both groups,but the effective rate in treatment group was significantly higher than that in the control group (78.3％ vs.55.0％,x2 =4.97,P ＜ 0.05).The therapy effects were poorer and the medical care expenses were bigher in control goup than therapy group (P=0.013).Conclusions Yiqing Capsule combined with antibacterial agents can synergisticly enhance the clinical therapeutic effect and significantly reduce the length of hospitalization,being of great value to economy.