CAJ | 학술논문

随着对肿瘤逃避免疫监视机制研究的不断深入,免疫治疗已成为一种有希望治疗肿瘤的新方法.其中肿瘤疫苗作为肿瘤的特异性主动免疫治疗成为肺癌非常有吸引力的靶向治疗策略之一,尤其适用于完全切除术后患者的辅助治疗.近年来肿瘤疫苗是采用MAGE多肽、基因和树突状细胞等方法来免疫肺癌患者,在Ⅰ/Ⅱ期临床试验中已观察到免疫反应和肿瘤的缓解,并取得了较好的临床疗效评价.目前正在进行国际多中心临床研究进行论证.
수착대종류도피면역감시궤제연구적불단심입,면역치료이성위일충유희망치료종류적신방법.기중종류역묘작위종류적특이성주동면역치료성위폐암비상유흡인력적파향치료책략지일,우기괄용우완전절제술후환자적보조치료.근년래종류역묘시채용MAGE다태、기인화수돌상세포등방법래면역폐암환자,재Ⅰ/Ⅱ기림상시험중이관찰도면역반응화종류적완해,병취득료교호적림상료효평개.목전정재진행국제다중심림상연구진행론증.
As the tumor to evade immune surveillance mechanism for the continuous in-depth research,immunotherapy has become a promising new method for treatment of cancer. One cancer vaccine as a tumor-specific active immunotherapy of lung cancer becomes a very attractive strategy of targeted therapy,especially for patients with completely resected adjuvant therapy. In recent years,cancer vaccines is the use of MAGE peptides,genes,and dendritic cells in patients with lung cancer,tumor immune response and mitigation have been observed in phase Ⅰ / Ⅱ clinical trials,and good clinical evaluation achieved.Ongoing international multi-center clinical study will demonstrate it.