中华内分泌代谢杂志
中華內分泌代謝雜誌
중화내분비대사잡지
CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2008年
6期
613-615
,共3页
朱素娟%金行一%徐卫民%吴龙%王衡%杨洋%王佳%汤益%金涛%许向军%唐爱奇%周建华%付延涨%阎玉芹
硃素娟%金行一%徐衛民%吳龍%王衡%楊洋%王佳%湯益%金濤%許嚮軍%唐愛奇%週建華%付延漲%閻玉芹
주소연%금행일%서위민%오룡%왕형%양양%왕가%탕익%금도%허향군%당애기%주건화%부연창%염옥근
妊娠%尿碘%甲状腺功能
妊娠%尿碘%甲狀腺功能
임신%뇨전%갑상선공능
Pregnancy%Urinary iodine%Thyroid function
目的 研究杭州市妊娠妇女在不同妊娠期尿碘及甲状腺功能状况,为今后实施孕妇的碘营养监测或孕妇甲状腺功能筛查提供依据.方法 随机抽取杭州市五个调查点395人进行尿碘、血清TSH、FT3、FT4检测,采用酸消化砷.铈接触法测定尿碘,化学发光法测定TSH、FT3、FT4水平.结果 (1)妊娠早、中、晚期妇女的尿碘中位数分别为170.3、170.2、162.4μg/L,均显著低于非妊娠妇女(对照组中位数251.9μg/L,均P<0.05);(2)妊娠早期妇女TSH水平显著低于对照组(P<0.05);妊娠中、晚期妇女FT4、FT3水平显著低于对照组(P<0.05);(3)104例妊娠中期妇女中有8.7%的人FT4低于下限值,9.6%的人FT3低于下限值;97例妊娠晚期妇女中有22.7%的人FT4低于下限值,17.5%的人FT3低于下限值.结论 从群体的角度来看,大多数杭州市妊娠妇女碘营养处于适宜水平;不能以非妊娠妇女甲状腺功能指标来判定妊娠妇女的甲状腺激素水平;妇女妊娠期不仅要进行尿碘监测,且应进行甲状腺功能筛查.
目的 研究杭州市妊娠婦女在不同妊娠期尿碘及甲狀腺功能狀況,為今後實施孕婦的碘營養鑑測或孕婦甲狀腺功能篩查提供依據.方法 隨機抽取杭州市五箇調查點395人進行尿碘、血清TSH、FT3、FT4檢測,採用痠消化砷.鈰接觸法測定尿碘,化學髮光法測定TSH、FT3、FT4水平.結果 (1)妊娠早、中、晚期婦女的尿碘中位數分彆為170.3、170.2、162.4μg/L,均顯著低于非妊娠婦女(對照組中位數251.9μg/L,均P<0.05);(2)妊娠早期婦女TSH水平顯著低于對照組(P<0.05);妊娠中、晚期婦女FT4、FT3水平顯著低于對照組(P<0.05);(3)104例妊娠中期婦女中有8.7%的人FT4低于下限值,9.6%的人FT3低于下限值;97例妊娠晚期婦女中有22.7%的人FT4低于下限值,17.5%的人FT3低于下限值.結論 從群體的角度來看,大多數杭州市妊娠婦女碘營養處于適宜水平;不能以非妊娠婦女甲狀腺功能指標來判定妊娠婦女的甲狀腺激素水平;婦女妊娠期不僅要進行尿碘鑑測,且應進行甲狀腺功能篩查.
목적 연구항주시임신부녀재불동임신기뇨전급갑상선공능상황,위금후실시잉부적전영양감측혹잉부갑상선공능사사제공의거.방법 수궤추취항주시오개조사점395인진행뇨전、혈청TSH、FT3、FT4검측,채용산소화신.시접촉법측정뇨전,화학발광법측정TSH、FT3、FT4수평.결과 (1)임신조、중、만기부녀적뇨전중위수분별위170.3、170.2、162.4μg/L,균현저저우비임신부녀(대조조중위수251.9μg/L,균P<0.05);(2)임신조기부녀TSH수평현저저우대조조(P<0.05);임신중、만기부녀FT4、FT3수평현저저우대조조(P<0.05);(3)104례임신중기부녀중유8.7%적인FT4저우하한치,9.6%적인FT3저우하한치;97례임신만기부녀중유22.7%적인FT4저우하한치,17.5%적인FT3저우하한치.결론 종군체적각도래간,대다수항주시임신부녀전영양처우괄의수평;불능이비임신부녀갑상선공능지표래판정임신부녀적갑상선격소수평;부녀임신기불부요진행뇨전감측,차응진행갑상선공능사사.
Objective To investigate the urinary iodine level and thyroid function during different trimesters of pregnancy in Hangzhou residents and to provide evidence for monitoring iodine nutrition or screening thyroid function. Methods The urinary iodine level and thyroid function of 395 subjects from 5 hospitals in Hanzhou were investigated. The urinary iodine level was measured by arsenic-cerium contact process method. The serum TSH, FT3 and FT4 were measured by chemiluminescence method. Results (1) The urinary iodine median concentration during pregnancy in the 1st, 2nd and 3rd trimesters were 170.3, 170.2, 162.4 μ/L respectively, all significantly lower than that of non-pregnant women (251.9 μg/L, all P < 0.05); (2) The mean value of TSH during the 1st trimester of pregnancy was significantly lower than that of non-preguant women (P < 0.05). The mean values of FT4 and FT3 in the 2nd and the 3rd trimesters of pregnancy were significantly lower than those of the control (P < 0.05); (3) During 2nd trimester, there were 8.7% (9/104, in FT4) and 9.6% (10/104, in FT3) pregnant women below normal lower range while during 3rd trimester, these figures reached 22.7% (22/97) and 17.5% (17/97) resfectively. Conclusions More than half of the pregnant women in Hangzhou have good nutritional status of iodine. There are significant differences in thyroid hormone levels between the non-pregnant and pregnant women as well as between gestation periods. Therefore, it is necessary to establish a trimester-specific reference range of thyroid hormones for normal pregnancy. The screening for thyroid function is recommended for pregnant women besides monitoring routine urinary iodine.
