CAJ | 학술논문

目的燕地黄常出现于治疗类风湿性关节炎的方剂中,本文用完全弗氏佐剂诱导大鼠足趾炎症,旨在验证其是否具有抗炎作用.方法于大鼠右后足趾皮内注射完全弗氏佐剂100μL.致炎后第19天,灌胃给予高、中、低剂量的熟地黄[0.625,1.250,2.500 g/(kg·体重)],10 d,以地塞米松为阳性药物,记录大鼠体重和足趾体积变化;第29天,测定脏器、血液参数,取足趾肉垫切片观察.结果模型组大鼠足趾持续肿胀,淋巴细胞浸润,胸腺和脾脏指数下降,血小板显著减少,其它指标与对照组差异不显著.燕地黄未显示抗炎作用,但可使胸腺和脾脏指数,以及血小板计数恢复正常,使肌酐水平显著上升.地塞米松抗炎作用显著,但同时存在多项毒副作用.结论熟地黄在治疗类风湿性关节炎的方剂中主要发挥辅助作用.
목적 연지황상출현우치료류풍습성관절염적방제중,본문용완전불씨좌제유도대서족지염증,지재험증기시부구유항염작용.방법 우대서우후족지피내주사완전불씨좌제100μL.치염후제19천,관위급여고、중、저제량적숙지황[0.625,1.250,2.500 g/(kg·체중)],10 d,이지새미송위양성약물,기록대서체중화족지체적변화;제29천,측정장기、혈액삼수,취족지육점절편관찰.결과 모형조대서족지지속종창,림파세포침윤,흉선화비장지수하강,혈소판현저감소,기타지표여대조조차이불현저.연지황미현시항염작용,단가사흉선화비장지수,이급혈소판계수회복정상,사기항수평현저상승.지새미송항염작용현저,단동시존재다항독부작용.결론 숙지황재치료류풍습성관절염적방제중주요발휘보조작용.
Purpose To investigate the anti-inflammatory effect of Radix Rehmanniae Praeparata(RRP)on the footpad inflammation induced by complete Freund's adjuvant(CFA)in rats.Methods CFA 100 μL were injected subcutaneously to the Wistar rats at the pad of right hindfoots.19 days later,the rats were daily siven RRP water extract(0.625,1.250,2.500 g/kg·bw)or dexamethasone(0.5mg/ks·bw)intragastrically.The changes of body weight and foot volume were measured.The indexes of organ and blood were determined at the 29th day,the foot pad was removed,and routine paraffin section was performed.Results The model rats kept foot swelling and lymphocyte infiltrating,and the platelet number decreased.The other indexes were statistically insignificant when compared to the controls.RRP did not display any anti-inflammatory effect on the swollon foots,but thoracic gland and spleen indexes were rescued,and platelet number and creatinine content were increased by RRP administration in a dose-dependent manner.The anti-inflammation of dexamethasone was conspicuous,but the side effects were also significant.Conclusion RRP may be plays an adjunctive action in herbal recipes to treat rheumatoid arthritis.