中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2011年
3期
273-276
,共4页
血浆致动脉硬化指数%2型糖尿病%动脉粥样硬化%内膜中膜厚度
血漿緻動脈硬化指數%2型糖尿病%動脈粥樣硬化%內膜中膜厚度
혈장치동맥경화지수%2형당뇨병%동맥죽양경화%내막중막후도
Atherogenic index of plasma%Type 2 diabetes%Atherosclerosis%Intima media thickness
目的 探讨血浆致动脉硬化指数(AIP)与2型糖尿病足背动脉粥样硬化病变程度的关系.方法 选取我院2型糖尿病患者127例,其中足背动脉粥样硬化66例,非动脉粥样硬化61例,选择我院同期体检健康者33名为健康对照组,应用彩色多普勒超声测定其足背动脉内膜中膜厚度(IMT),并测定其血甘油三酯、高密度脂蛋白胆固醇等代谢指标,计算AIP.用单因素方差分析比较3组各指标差异,并对各指标进行Pearson相关性分析.应用ROC曲线确定AIP对2型糖尿病足背动脉粥样硬化的最佳诊断工作点(OOP).结果 动脉粥样硬化组、非动脉粥样硬化组和健康对照组AIP分别为0.229±0.132、0.112±0.074、-0.045±0.033,IMT分别为(0.71±0.24)、(0.49±0.09)、(0.34±0.15)mm,组间差异均有统计学意义(F值分别为88.015、54.892,P值均为0.001).经校正可能的影响因素,AIP仍与IMT呈正相关(r=0.315,P=0.001).AIP的最佳诊断工作点为0.1671,曲线下面积为0.783.结论 AIP与2型糖尿病足背动脉粥样硬化相关性良好,其OOP具有较好的诊断参考价值.
目的 探討血漿緻動脈硬化指數(AIP)與2型糖尿病足揹動脈粥樣硬化病變程度的關繫.方法 選取我院2型糖尿病患者127例,其中足揹動脈粥樣硬化66例,非動脈粥樣硬化61例,選擇我院同期體檢健康者33名為健康對照組,應用綵色多普勒超聲測定其足揹動脈內膜中膜厚度(IMT),併測定其血甘油三酯、高密度脂蛋白膽固醇等代謝指標,計算AIP.用單因素方差分析比較3組各指標差異,併對各指標進行Pearson相關性分析.應用ROC麯線確定AIP對2型糖尿病足揹動脈粥樣硬化的最佳診斷工作點(OOP).結果 動脈粥樣硬化組、非動脈粥樣硬化組和健康對照組AIP分彆為0.229±0.132、0.112±0.074、-0.045±0.033,IMT分彆為(0.71±0.24)、(0.49±0.09)、(0.34±0.15)mm,組間差異均有統計學意義(F值分彆為88.015、54.892,P值均為0.001).經校正可能的影響因素,AIP仍與IMT呈正相關(r=0.315,P=0.001).AIP的最佳診斷工作點為0.1671,麯線下麵積為0.783.結論 AIP與2型糖尿病足揹動脈粥樣硬化相關性良好,其OOP具有較好的診斷參攷價值.
목적 탐토혈장치동맥경화지수(AIP)여2형당뇨병족배동맥죽양경화병변정도적관계.방법 선취아원2형당뇨병환자127례,기중족배동맥죽양경화66례,비동맥죽양경화61례,선택아원동기체검건강자33명위건강대조조,응용채색다보륵초성측정기족배동맥내막중막후도(IMT),병측정기혈감유삼지、고밀도지단백담고순등대사지표,계산AIP.용단인소방차분석비교3조각지표차이,병대각지표진행Pearson상관성분석.응용ROC곡선학정AIP대2형당뇨병족배동맥죽양경화적최가진단공작점(OOP).결과 동맥죽양경화조、비동맥죽양경화조화건강대조조AIP분별위0.229±0.132、0.112±0.074、-0.045±0.033,IMT분별위(0.71±0.24)、(0.49±0.09)、(0.34±0.15)mm,조간차이균유통계학의의(F치분별위88.015、54.892,P치균위0.001).경교정가능적영향인소,AIP잉여IMT정정상관(r=0.315,P=0.001).AIP적최가진단공작점위0.1671,곡선하면적위0.783.결론 AIP여2형당뇨병족배동맥죽양경화상관성량호,기OOP구유교호적진단삼고개치.
Objective To investigate the relationship between Atherogenic Index of Plasma(AIP) and the dorsalis pedis artery atherosclerosis in type 2 diabetes. Methods One hundred and twenty-seven patients with type 2 diabetes and 33 healthy individuals were included in the study. The diabetic patients were devided into 2 groups, with( n = 66) or without ( n = 61 ) atherosclerosis. The intima media thickness (IMT) of dorsalis pedis artery were measured by B-mode Doppler ultrasonography. The triglyceride(TG) ,high density lipoproteincholesterol(HDL-C) and other glucolipid metabolic indices were measured in all patients. The AIP was defined as the log value of TG/HDL-C ratio. The one-way ANOVA test was performed to determine the differences among three groups. The relationships between IMT and the other indicators were assessed using Pearson bivariate correlations analysis. The optimal operating point of AIP to diagnose the dorsalis pedis artery atherosclerosis in type 2 diabetes was obtained by drawing ROC curve. Results The AIP value in atherosclerosis diabetic patients,no-atherosclerosis diabetic patients and healthy subjects were 0. 229 ± 0. 132,0. 112 ± 0. 074 and -0. 045 ± 0. 033 respectively. The IMT value were (0. 71 ± 0. 24 ) mm, (0. 49 ± 0. 09 ) mm and (0. 34 ± 0. 15 ) mm respectively. Both indices shown statistical differences among the three groups (Ps = 0. 001 respectively). After adjusting for potential influence factors, AIP showed positive correlation with IMT( r = 0. 315, P = 0. 001 ). The OOP of AIP was 0. 1671 ,the area under the curve was 0. 783. Conclusion AIP was well related to the dorsalis pedis artery atherosclerosis in type 2 diabetes,and the OOP of AIP had good diagnostic reference value in these patients.
