CAJ | 학술논문

背景右美托咪啶(dexmedetomidine,DEX)是新一代高选择性α2肾上腺素能受体激动剂,具有镇静、镇痛和抗交感作用.虽然DEX还未被批准用于18岁以下患者,但已有许多在小儿心脏外科使用的文献报道.目的总结DEX在先天性心脏病(先心病)患儿中的临床应用近况.内容除最常用于围术期重症监护治疗外,DEX在小儿心脏外科还可用于各种诊疗时的镇静、作为麻醉辅助用药、治疗快速型室上性心动过速和治疗阿片药及苯二氮萆类药物的撤药反应.趋向 DEX的安全范围较宽,对呼吸影响小,特别是对心肺功能严重受损的重症先心病患儿能发挥独特的优势.
배경 우미탁미정(dexmedetomidine,DEX)시신일대고선택성α2신상선소능수체격동제,구유진정、진통화항교감작용.수연DEX환미피비준용우18세이하환자,단이유허다재소인심장외과사용적문헌보도.목적 총결DEX재선천성심장병(선심병)환인중적림상응용근황.내용 제최상용우위술기중증감호치료외,DEX재소인심장외과환가용우각충진료시적진정、작위마취보조용약、치료쾌속형실상성심동과속화치료아편약급분이담비류약물적철약반응.추향 DEX적안전범위교관,대호흡영향소,특별시대심폐공능엄중수손적중증선심병환인능발휘독특적우세.
Background Dexmedetomidine(DEX)is a novel highly selective α2-adrenoceptor agonist with sedative,analgesic,and anxiolytic effects.Although it has not been approved by the US FDA for pediatric patients under 18 years old,there are a lot of literatures focusing on its using in pediatric patients with congenital heart disease.Objective This paper discusses the application of DEX in children with congenital heart disease in detail.Content The clinical applications of DEX in cardiac surgery include sedative in pediatric intensive care unit,sedation during non-invasive and invasive procedures,as part of multimodal anesthetic regimen,treatment of supraventricular tachyarrhymias and prevention of drug withdrawal.Trend DEX is a safe chug while using in critically ill patients,with advantage of wide dose range and minimal respiratory depression.