CAJ | 학술논문

目的探讨慢性充血性心力衰竭(CHF)患者血浆B型脑钠肽(BNP)及NT-pro BNP改变及其临床意义.方法对该院明确诊断为CHF的120例不同病因、不同心功能分级的慢性充血性心衰患者及50例对照组,测定入院时血浆NT-pro BNP及LVEDD、LVESD、LVEF变化,并进行治疗前后对比观察.结果 CHF组总体血浆NT-pro BNP水平明显高于对照组(P<0.05),NYHA Ⅰ级心功能时血浆BNP明显高于对照组(P<0.05),且Ⅰ、Ⅱ、Ⅲ、Ⅳ级组间血浆BNP依次递增(P<0.05).CHF在治疗后明显低于治疗前(P<0.05).结论血浆NT-pro BNP的水平对CHF的诊断、严重程度和预后评价有重要价值.
목적 탐토만성충혈성심력쇠갈(CHF)환자혈장B형뇌납태(BNP)급NT-pro BNP개변급기림상의의.방법 대해원명학진단위CHF적120례불동병인、불동심공능분급적만성충혈성심쇠환자급50례대조조,측정입원시혈장NT-pro BNP급LVEDD、LVESD、LVEF변화,병진행치료전후대비관찰.결과 CHF조총체혈장NT-pro BNP수평명현고우대조조(P<0.05),NYHA Ⅰ급심공능시혈장BNP명현고우대조조(P<0.05),차Ⅰ、Ⅱ、Ⅲ、Ⅳ급조간혈장BNP의차체증(P<0.05).CHF재치료후명현저우치료전(P<0.05).결론 혈장NT-pro BNP적수평대CHF적진단、엄중정도화예후평개유중요개치.
Objective To evaluate the clinical significance of the changes of plasma B-type natriuretic paprid and NT-pro BNP levels in patients with chronic heart failure(CHF).Methods 120 consecutive patients hospitalized for CHF were retrospectively studied.NT-pro BNP and LVEDD,LVESD,LVEF were measured and compared in 120 patients and 50 normal control subjects before medical treatment and on discharge.Results The plasma NT-pro BNP levels in patients with CHF were significantly higher than controls( P <0.05).The plasma NT-pro BNP levels in patients with cardiac function NYHA Ⅰ were significantly higher than controls( P < 0.05).As the cardiac function deteriorated from NYNA Ⅰ to NYNA Ⅳ,the NT-pro BNP levels increased consecutively with significant differences from each other ( P < 0.05).The plasma NT-pro BNP levels was low when CHF was cured ( P < 0.05 ).Conclusion Determination of plasma NT-pro BNP levels in patients with CHF were helpful to study the severity and prognosis of disease.