CAJ | 학술논문

目的观察三维适形放射治疗(3DCRT)配合化疗治疗局部晚期(NSCLC)的近期疗效及毒副反应.方法 36例局部晚期NSCLC(Ⅲa或HI b期)进入三维适形放射治疗加化疗组,均行NP方案化疗并加3DCRT同步治疗.结果 36例均完成治疗计划,肺原发灶总有效率为91.7%,纵隔转移淋巴结总有效率为100%,白细胞下降发生率为94.4%,放射性食管炎和放射性肺炎的发生率分别为52.8%、11.1%,均为1、2级.结论三维适形放射治疗配合化疗治疗局部晚期非小细胞肺癌能为绝大数患者耐受,近期疗效满意.
목적 관찰삼유괄형방사치료(3DCRT)배합화료치료국부만기(NSCLC)적근기료효급독부반응.방법 36례국부만기NSCLC(Ⅲa혹HI b기)진입삼유괄형방사치료가화료조,균행NP방안화료병가3DCRT동보치료.결과 36례균완성치료계화,폐원발조총유효솔위91.7%,종격전이림파결총유효솔위100%,백세포하강발생솔위94.4%,방사성식관염화방사성폐염적발생솔분별위52.8%、11.1%,균위1、2급.결론 삼유괄형방사치료배합화료치료국부만기비소세포폐암능위절대수환자내수,근기료효만의.
Objective To evaluate the acute side effects and efficacy of three dimensional conformal radiotherapy(3DCRT)combined with chemotherapy(CT)for locally advance non-small cell lung cancer(NSCLC).Methods from May.2002 tO Dec 2004,36 patients with NSCLC were treated with three dimensional-conformal radiotherapy combined with chemotherapy navelbine+cisplafin(NP)Results The overall response rate(CR+PR)was 91.7% for the primary tumor,and 100%for metastases mediastinal lymph mode.The leucopenia mte was 94.4%(55.6%Grade 3.4)Acute radiation esophagitis occurred in 52.8%of patients(Grade 1.2)Acute radiation pneumonitis was observed in 11.1%of patients(Grade 1.2)Conclusion 3DCRT combined with CT is well tolerated in most patients with NSCLC.Its early responses are milder than the conventional radiotherapy combined with chemotherapy.Remote results awmt further follow-up