CAJ | 학술논문

目的：研究盐酸西布曲明的合成方法。方法：以对氯氰苄为起始原料经环合、格氏反应、还原、氮上的氮甲基化、成盐5步反应合成盐酸西布曲明，并对反应的条件进行了优化。结果：经5步反应合成盐酸西布曲明，总收率为40.6%。结论：反应条件温和，工艺简便，收率较高，适用于工业化生产。
목적：연구염산서포곡명적합성방법。방법：이대록청변위기시원료경배합、격씨반응、환원、담상적담갑기화、성염5보반응합성염산서포곡명，병대반응적조건진행료우화。결과：경5보반응합성염산서포곡명，총수솔위40.6%。결론：반응조건온화，공예간편，수솔교고，괄용우공업화생산。
OBJECTIVE:To study the synthesis of sibutramine hydrochloride.METHODS:Sibutramine hydrochloride was synthesized from the starting material 4-chlorobenzylcyanide by cyclization，Grignard reaction，reduction，methylation to afford sibutramine which followed by salt formation with hydrochloride，the conditions in synthesis were improved.RESULTS:Sibutramine hydrochloride was synthesized from 4-chlorobenzylcyanide. The overall yield was 40.6%. CONCLUSION:The methed was more suitable for mass manufacture.