福州大学学报（自然科学版）
福州大學學報（自然科學版）
복주대학학보（자연과학판）
JOURNAL OF FUZHOU UNIVERSITY(NATURAL SCIENCE EDITION)
2004年
5期
623-626
,共4页
分离%双水相%扁桃酸%聚乙二醇
分離%雙水相%扁桃痠%聚乙二醇
분리%쌍수상%편도산%취을이순
partitioning%aqueous two-phase system%D(-)-mandelic acid%polyethylene glycol
采用聚乙二醇-硫酸铵双水相系统分离手性药物扁桃酸.研究了聚乙二醇分子量、相组成、pH值和温度对扁桃酸分离的影响.结果表明,聚乙二醇分子量对双水相分离扁桃酸的影响最大;温度对扁桃酸的分离几乎没有影响;随pH增大,扁桃酸分配系数减少.
採用聚乙二醇-硫痠銨雙水相繫統分離手性藥物扁桃痠.研究瞭聚乙二醇分子量、相組成、pH值和溫度對扁桃痠分離的影響.結果錶明,聚乙二醇分子量對雙水相分離扁桃痠的影響最大;溫度對扁桃痠的分離幾乎沒有影響;隨pH增大,扁桃痠分配繫數減少.
채용취을이순-류산안쌍수상계통분리수성약물편도산.연구료취을이순분자량、상조성、pH치화온도대편도산분리적영향.결과표명,취을이순분자량대쌍수상분리편도산적영향최대;온도대편도산적분리궤호몰유영향;수pH증대,편도산분배계수감소.
Studies on the partition of D (-)-mandelic acid were performed in polyethylene glycol (PEG) with molecular masses of 2000, 4000, 6000, 10000, 20000- ammonium sulfate systems. The effect of various parameters such as molecular mass of PEG, phase composition, pH of the system and temperature were investigated in this work. The results indicate that the molecular mass of PEG is a key factor affecting the partitioning behaviors of D(-)-mandelic acid in the PEG -(NH4)2SO4 systems. The influence of pH on the partition shows that the partition coefficient of D(-)-mandelic acid decreases with the increase of pH value. D(-)-mandelic acid partition is only slightly influenced by the temperature. All these indicate that the aqueous two-phase is a very suitable alternative system for the separation of D(-)-mandelic acid.
