CAJ | 학술논문

胸腺是哺乳动物重要的中枢免疫器官,是决定和制约免疫系统老化的关键.胸腺作为T 细胞分化、发育、成熟重要场所,随着增龄表现出明显萎缩的现象进而影响到T细胞的发育、增殖和输出,从而造成外周淋巴组织中T细胞的质与量的异常,这样就不可避免地降低了免疫系统对外来的抗原应答性,导致病原体清除延迟,增加了老年人罹患癌症、自身免疫性疾病以及病毒、细菌等病原感染的风险,了解胸腺增龄性萎缩过程中转录因子、细胞因子的作用及增龄性萎缩胸腺功能恢复调节研究概况很有必要.
흉선시포유동물중요적중추면역기관,시결정화제약면역계통노화적관건.흉선작위T 세포분화、발육、성숙중요장소,수착증령표현출명현위축적현상진이영향도T세포적발육、증식화수출,종이조성외주림파조직중T세포적질여량적이상,저양취불가피면지강저료면역계통대외래적항원응답성,도치병원체청제연지,증가료노년인리환암증、자신면역성질병이급병독、세균등병원감염적풍험,료해흉선증령성위축과정중전록인자、세포인자적작용급증령성위축흉선공능회복조절연구개황흔유필요.
The thymus is the most important central immune organ of mammals which determines the aging of immune system. It is the major site of T cell maturation where extensive proliferation and differentiation occur. Age-related deterioration of the thymus can affect the function of peripheral T cells, which inevitably impairs the responsiveness of immune system to foreign antigens, leading to delayed clearance of pathogens. This also increases the risk of elderly people suffering from cancer, autoimmune diseases and infections diseases caused by viruses, bacteria and other pathogens. This review presents the latest information on the role of transcription factors and cytokines in the progress of age-related thymic involution. We also review the studies on the regulation of the functional recovery of thymus.