CAJ | 학술논문

慢性阻塞性肺疾病(COPD)是由慢性气道和肺实质炎症引起的进行性气流受限的阻塞性疾病,气流受限不完全可逆.COPD是全球范围内慢性病发病和死亡的重要原因,而气道黏液高分泌是COPD发病和死亡的重要因素.黏液高分泌导致黏液纤毛清除受损、细菌定植、气道黏液栓形成以及气体交换功能障碍.为了阻止这个恶性循环,必须控制气道慢性炎症和减少黏液高分泌.因此,了解黏液特性和黏液高分泌机制对于医师来说是很重要的.
만성조새성폐질병(COPD)시유만성기도화폐실질염증인기적진행성기류수한적조새성질병,기류수한불완전가역.COPD시전구범위내만성병발병화사망적중요원인,이기도점액고분비시COPD발병화사망적중요인소.점액고분비도치점액섬모청제수손、세균정식、기도점액전형성이급기체교환공능장애.위료조지저개악성순배,필수공제기도만성염증화감소점액고분비.인차,료해점액특성화점액고분비궤제대우의사래설시흔중요적.
Chronic obstructive pulmonary disease (COPD) is an obstructive disorder of progressive airflow limitation caused by chronic airway and lung parenchyma inflammation that is not fully reversible.COPD is a major cause of chronic morbidity and mortality worldwide.However mucus hypersecretion in the airway is an important factor in the morbidity and mortality of COPD.Airway mucus hypersecretion leads to impairment of mucociliary clearance,bacterial plantation,mucus plug in the airway,and dysfunction of gas exchange.To block this vicious cycle,chronic inflammation in the airway must be controlled and mucus hypersecretion must be reduced.So,It is important for physicians to learn about the characteristics of mucus,mechanism of mucus hypersecretion.