中华放射医学与防护杂志
中華放射醫學與防護雜誌
중화방사의학여방호잡지
Chinese Journal of Radiological Medicine and Protection
2010年
1期
33-36
,共4页
季永领%许亚萍%马胜林%孙晓江%王健%狄小云
季永領%許亞萍%馬勝林%孫曉江%王健%狄小雲
계영령%허아평%마성림%손효강%왕건%적소운
非小细胞肺癌%放射疗法%调强适形%靶区勾画
非小細胞肺癌%放射療法%調彊適形%靶區勾畫
비소세포폐암%방사요법%조강괄형%파구구화
Non-small cell lung cancer%Radiotherapy%Intensity-modulated irradiation%Target delineation
目的 探讨非小细胞肺癌调强放疗计划设计的合理方案.方法 对11例非小细胞肺癌患者分别制定2种放疗计划:PTV60计划的PTV为(GTV+6-8 mm)+呼吸动度+摆位误差,对PTV获得60 Gy处方剂量进行归一;PTV70计划的PTV为GTV+呼吸动度+摆位误差,对PTV获得70 Gy处方剂量进行归一.通过剂量体积直方图分析2种治疗计划的靶区剂量分布和危及器官受量,并进行剂量学的对比研究.结果 PTV70计划接受60 Gy剂量的靶区体积明显高于PTV60计划.两组在靶区剂量均匀性方面相似.PTV70计划的肺V_(20)较PTV60计划平均下降(1.69 4±0.42)%,两组相比差异有统计学意义(t＝0.047,P＝0.002);肺V_5平均下降(1.29 ±1.09)%,两组相比差异无统计学意义.结论 在非小细胞肺癌调强放疗设计中,PTV70计划优于PTV60计划.
目的 探討非小細胞肺癌調彊放療計劃設計的閤理方案.方法 對11例非小細胞肺癌患者分彆製定2種放療計劃:PTV60計劃的PTV為(GTV+6-8 mm)+呼吸動度+襬位誤差,對PTV穫得60 Gy處方劑量進行歸一;PTV70計劃的PTV為GTV+呼吸動度+襬位誤差,對PTV穫得70 Gy處方劑量進行歸一.通過劑量體積直方圖分析2種治療計劃的靶區劑量分佈和危及器官受量,併進行劑量學的對比研究.結果 PTV70計劃接受60 Gy劑量的靶區體積明顯高于PTV60計劃.兩組在靶區劑量均勻性方麵相似.PTV70計劃的肺V_(20)較PTV60計劃平均下降(1.69 4±0.42)%,兩組相比差異有統計學意義(t＝0.047,P＝0.002);肺V_5平均下降(1.29 ±1.09)%,兩組相比差異無統計學意義.結論 在非小細胞肺癌調彊放療設計中,PTV70計劃優于PTV60計劃.
목적 탐토비소세포폐암조강방료계화설계적합리방안.방법 대11례비소세포폐암환자분별제정2충방료계화:PTV60계화적PTV위(GTV+6-8 mm)+호흡동도+파위오차,대PTV획득60 Gy처방제량진행귀일;PTV70계화적PTV위GTV+호흡동도+파위오차,대PTV획득70 Gy처방제량진행귀일.통과제량체적직방도분석2충치료계화적파구제량분포화위급기관수량,병진행제량학적대비연구.결과 PTV70계화접수60 Gy제량적파구체적명현고우PTV60계화.량조재파구제량균균성방면상사.PTV70계화적폐V_(20)교PTV60계화평균하강(1.69 4±0.42)%,량조상비차이유통계학의의(t＝0.047,P＝0.002);폐V_5평균하강(1.29 ±1.09)%,량조상비차이무통계학의의.결론 재비소세포폐암조강방료설계중,PTV70계화우우PTV60계화.
Objective To investigate the optimal treatment planning of intensity modulated radiotherapy (IMRT) for non-small cell lung cancer (NSCLC) .Methods Two types of treatment plans were designed for 11 patients with inoperable NSCLC disease.In the first plan(PTV60 plan) ,60 Gy was prescribed to the planning target volume(PTV) which was created using CTV(GTV +6-8 mm) plus the margin for organ motion and setup uncertainties.In the second plan(PTV70 plan) ,70 Gy was prescribed to the PTV which was created using GTV plus the margin for organ motion and setup uncertainties.The dose-volume histogram,the planning target volume coverage,and other dosimetric parameters of normal structures were compared between the two plans.Results These two plans were not significantly different in the dose heterogeneity,but commpared with the PTV60 plan,the PTV70 plan significantly improved 60 Gy volume with regard to PTV coverage.The values of V_(20) and V_5 of lung were reduced in average by (1.69 ±0.42) % ,and (1.29 ±1.09) % (t ＝ 0.047,0.264,P ＝ 0.002) ,respectively.Conclusions The planning of 70 Gy to the PTV using GTV plus the margin for organ motion and setup uncertainties might be better than that of 60 Gy to the PTV using CTV(GTV +6-8 mm) plus the margin for organ motion and setup uncertainties.
