中华劳动卫生职业病杂志
中華勞動衛生職業病雜誌
중화노동위생직업병잡지
CHINESE JOURNAL OF INDUSTRIAL HYGIENE AND OCCUPATIONAL DISEASES
2012年
9期
683-685
,共3页
冯峰%何百寅%叶雪兰%刘常青%谢友良%赖小平%周应军
馮峰%何百寅%葉雪蘭%劉常青%謝友良%賴小平%週應軍
풍봉%하백인%협설란%류상청%사우량%뢰소평%주응군
苯胺化合物%透皮肤吸收%手套,防护
苯胺化閤物%透皮膚吸收%手套,防護
분알화합물%투피부흡수%수투,방호
Aniline compounds%Skin absorption%Gloves,protection
目的 研究苯胺对完整小鼠腹皮的透过性和2种实验室常用手套对苯胺的防护作用.方法 采用Franz扩散池,进行0.102mg/ml和0.010 mg/ml的苯胺乙醇溶液体外经皮肤吸收试验和手套透过试验,以完整小鼠腹皮、手套为渗透屏障,高效液相色谱-二极管阵列检测器法测定苯胺的透过率.结果 2种浓度苯胺12h内透皮过程呈零级动力学规律,24 h累积透过率分别为51.71％和48.31％;吸收液中苯胺浓度至少为18 μg/L,医用一次性乳胶手套无法阻止0.010 mg/ml的苯胺渗透,天然乳胶工业手套可阻止渗透.结论 0.102和0.010 mg/ml的苯胺乙醇溶液12h内透过小鼠腹皮呈零级动力学规律；医用一次性乳胶手套不能完全阻止0.010 mg/ml的苯胺渗透,而天然乳胶工业手套可以阻止苯胺渗透.
目的 研究苯胺對完整小鼠腹皮的透過性和2種實驗室常用手套對苯胺的防護作用.方法 採用Franz擴散池,進行0.102mg/ml和0.010 mg/ml的苯胺乙醇溶液體外經皮膚吸收試驗和手套透過試驗,以完整小鼠腹皮、手套為滲透屏障,高效液相色譜-二極管陣列檢測器法測定苯胺的透過率.結果 2種濃度苯胺12h內透皮過程呈零級動力學規律,24 h纍積透過率分彆為51.71％和48.31％;吸收液中苯胺濃度至少為18 μg/L,醫用一次性乳膠手套無法阻止0.010 mg/ml的苯胺滲透,天然乳膠工業手套可阻止滲透.結論 0.102和0.010 mg/ml的苯胺乙醇溶液12h內透過小鼠腹皮呈零級動力學規律；醫用一次性乳膠手套不能完全阻止0.010 mg/ml的苯胺滲透,而天然乳膠工業手套可以阻止苯胺滲透.
목적 연구분알대완정소서복피적투과성화2충실험실상용수투대분알적방호작용.방법 채용Franz확산지,진행0.102mg/ml화0.010 mg/ml적분알을순용액체외경피부흡수시험화수투투과시험,이완정소서복피、수투위삼투병장,고효액상색보-이겁관진렬검측기법측정분알적투과솔.결과 2충농도분알12h내투피과정정령급동역학규률,24 h루적투과솔분별위51.71％화48.31％;흡수액중분알농도지소위18 μg/L,의용일차성유효수투무법조지0.010 mg/ml적분알삼투,천연유효공업수투가조지삼투.결론 0.102화0.010 mg/ml적분알을순용액12h내투과소서복피정령급동역학규률；의용일차성유효수투불능완전조지0.010 mg/ml적분알삼투,이천연유효공업수투가이조지분알삼투.
Objective To study the permeability of intact mouse abdominal skin to aniline and the protective capability of two typical lab gloves against aniline.Methods A Franz diffusion cell was used to perform in vitro transdermal absorption test and glove permeation test for aniline (0.102 mg/ml and 0.010 mg/ml).The permeabilities of intact mouse abdominal skin and gloves to aniline were measured by high performance liquid chromatography-diode array detection.Results The transdermal penetration of the two concentrations of aniline followed zero order kinetics within 12 h,exhibiting total aniline permeabilities within 24 h of 51.71％and 48.31％,respectively.The absorption liquid had an aniline concentration of at least 18 μg/L.The medical disposable latex glove could not stop the penetration of 0.010 mg/ml aniline,but the industrial natural latex glove could.Conclusion The penetration of 0.102 mg/ml and 0.010 mg/ml aniline through the mouse abdominal skin follows zero order kinetics within 12 h.The medical disposable latex glove cannot stop the penetration of 0.010 mg/ml aniline,but the industrial natural latex glove can.
