中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2010年
14期
1909-1910
,共2页
太子参多糖%糖尿病大鼠%肿瘤坏死因子-α%消脂素
太子參多糖%糖尿病大鼠%腫瘤壞死因子-α%消脂素
태자삼다당%당뇨병대서%종류배사인자-α%소지소
Pseudostellaria Polysaccharides%diabetic rats%TNF-α%Leption
目的 研究太子参多糖对实验性糖尿病大鼠降糖作用机制.方法 糖尿病模型采用大鼠腹腔注射四氧嘧啶200 mg/kg制作,观察太子参多糖不同剂量对糖尿病模型大鼠消脂素和肿瘤坏死因子-α的影响.结果 中、高剂量太子参多糖(0.6 g/kg,1.2g/kg)能显著升高糖尿病大鼠血清消脂素水平,同时能降低糖尿病大鼠血清肿瘤坏死因子-α水平(P＜0.05或P＜0.01).结论 太子参多糖能通过多个途径发挥对实验性糖尿病大鼠的治疗作用.
目的 研究太子參多糖對實驗性糖尿病大鼠降糖作用機製.方法 糖尿病模型採用大鼠腹腔註射四氧嘧啶200 mg/kg製作,觀察太子參多糖不同劑量對糖尿病模型大鼠消脂素和腫瘤壞死因子-α的影響.結果 中、高劑量太子參多糖(0.6 g/kg,1.2g/kg)能顯著升高糖尿病大鼠血清消脂素水平,同時能降低糖尿病大鼠血清腫瘤壞死因子-α水平(P＜0.05或P＜0.01).結論 太子參多糖能通過多箇途徑髮揮對實驗性糖尿病大鼠的治療作用.
목적 연구태자삼다당대실험성당뇨병대서강당작용궤제.방법 당뇨병모형채용대서복강주사사양밀정200 mg/kg제작,관찰태자삼다당불동제량대당뇨병모형대서소지소화종류배사인자-α적영향.결과 중、고제량태자삼다당(0.6 g/kg,1.2g/kg)능현저승고당뇨병대서혈청소지소수평,동시능강저당뇨병대서혈청종류배사인자-α수평(P＜0.05혹P＜0.01).결론 태자삼다당능통과다개도경발휘대실험성당뇨병대서적치료작용.
Objective To investigate potential mechanism of decreasiy leptin level of Pseudostellaria Polysaccharides on experimental diabetic rats. Methods The diabetic rats were induced by the abdominal cavity injection of alloxen(ALX) 200 mg· kg-1. The levels of leption and TNF-α were determined. Results Pseudostellaria Polysaccharides (0.6 g·kg-1 , 1.2 g·kg-1 ) could increase Leptin level and could decrease TNF-α level of DM rats(P＜0.05 or P＜0.01). Conclusion Pseudostellaria Polysaccharides can play an threpedtic rale in the experiment aldialetic rats through multi-pathway the experimental diabetic rats.
