中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2011年
30期
21-24
,共4页
赵玮%姜文兵%张东矗%于路%王毅%张建华
趙瑋%薑文兵%張東矗%于路%王毅%張建華
조위%강문병%장동촉%우로%왕의%장건화
冠状动脉疾病%尿酸%Gensini积分
冠狀動脈疾病%尿痠%Gensini積分
관상동맥질병%뇨산%Gensini적분
Coronary disease%Uric acid%Gensini coronary score
目的 探讨血尿酸水平与冠心病及其病变严重程度的相关性.方法 选取112例行冠状动脉造影的患者,分为3组,急性冠状动脉综合征(ACS)患者58例(ACS组),稳定型心绞痛患者25例(稳定型心绞痛组),非冠心病患者29例(对照组),进行血尿酸测定,冠状动脉病变程度用冠状动脉病变支数及Gensini积分表示,按病变范围分为对照组(29例)、单支病变组(24例)、双支病变组(26例)、三支病变组(33例);按Gensini积分分为0~1分组(29例)、2~20分组(28例)、21~40分组(30例)、>40分组(25例).结果 ACS组血尿酸水平显著高于对照组和稳定型心绞痛组[( 369.61±91.97)μmol/L比(298.33±92.46)、(330.43±87.42)μmol/L](P< 0.05).对照组血尿酸水平显著低于单支、双支和三支病变组[ (298.33±92.46)μmol/L比(331.77±86.33)、(368.24±95.21)、(396.82±94.45)μmol/L](P<0.05),单支病变组血尿酸水平显著低于双支病变组和三支病变组(P<0.05).0~1分组[(298.33±92.46)μmol/L]和2~20分组[(320.77±86.33)μmol/L]血尿酸水平显著低于21~40分组[(366.61 ±91.97) μmol/L]和>40分组[(402.82±91.97)μ mol/L](P<0.05).21 ~40分组血尿酸水平低于>40分组(P<0.05).血尿酸水平与Gensini积分的对数呈正相关(r=0.348,P< 0.05).结论 血尿酸与冠状动脉稳定性、狭窄程度以及范围显著相关,有助于临床评价冠心病病变程度及其进展.
目的 探討血尿痠水平與冠心病及其病變嚴重程度的相關性.方法 選取112例行冠狀動脈造影的患者,分為3組,急性冠狀動脈綜閤徵(ACS)患者58例(ACS組),穩定型心絞痛患者25例(穩定型心絞痛組),非冠心病患者29例(對照組),進行血尿痠測定,冠狀動脈病變程度用冠狀動脈病變支數及Gensini積分錶示,按病變範圍分為對照組(29例)、單支病變組(24例)、雙支病變組(26例)、三支病變組(33例);按Gensini積分分為0~1分組(29例)、2~20分組(28例)、21~40分組(30例)、>40分組(25例).結果 ACS組血尿痠水平顯著高于對照組和穩定型心絞痛組[( 369.61±91.97)μmol/L比(298.33±92.46)、(330.43±87.42)μmol/L](P< 0.05).對照組血尿痠水平顯著低于單支、雙支和三支病變組[ (298.33±92.46)μmol/L比(331.77±86.33)、(368.24±95.21)、(396.82±94.45)μmol/L](P<0.05),單支病變組血尿痠水平顯著低于雙支病變組和三支病變組(P<0.05).0~1分組[(298.33±92.46)μmol/L]和2~20分組[(320.77±86.33)μmol/L]血尿痠水平顯著低于21~40分組[(366.61 ±91.97) μmol/L]和>40分組[(402.82±91.97)μ mol/L](P<0.05).21 ~40分組血尿痠水平低于>40分組(P<0.05).血尿痠水平與Gensini積分的對數呈正相關(r=0.348,P< 0.05).結論 血尿痠與冠狀動脈穩定性、狹窄程度以及範圍顯著相關,有助于臨床評價冠心病病變程度及其進展.
목적 탐토혈뇨산수평여관심병급기병변엄중정도적상관성.방법 선취112례행관상동맥조영적환자,분위3조,급성관상동맥종합정(ACS)환자58례(ACS조),은정형심교통환자25례(은정형심교통조),비관심병환자29례(대조조),진행혈뇨산측정,관상동맥병변정도용관상동맥병변지수급Gensini적분표시,안병변범위분위대조조(29례)、단지병변조(24례)、쌍지병변조(26례)、삼지병변조(33례);안Gensini적분분위0~1분조(29례)、2~20분조(28례)、21~40분조(30례)、>40분조(25례).결과 ACS조혈뇨산수평현저고우대조조화은정형심교통조[( 369.61±91.97)μmol/L비(298.33±92.46)、(330.43±87.42)μmol/L](P< 0.05).대조조혈뇨산수평현저저우단지、쌍지화삼지병변조[ (298.33±92.46)μmol/L비(331.77±86.33)、(368.24±95.21)、(396.82±94.45)μmol/L](P<0.05),단지병변조혈뇨산수평현저저우쌍지병변조화삼지병변조(P<0.05).0~1분조[(298.33±92.46)μmol/L]화2~20분조[(320.77±86.33)μmol/L]혈뇨산수평현저저우21~40분조[(366.61 ±91.97) μmol/L]화>40분조[(402.82±91.97)μ mol/L](P<0.05).21 ~40분조혈뇨산수평저우>40분조(P<0.05).혈뇨산수평여Gensini적분적대수정정상관(r=0.348,P< 0.05).결론 혈뇨산여관상동맥은정성、협착정도이급범위현저상관,유조우림상평개관심병병변정도급기진전.
Objective To investigate the correlation between serum uric acid level and severity of coronary artery disease.Methods The concentrations of serum uric acid in 112 patients whom had received coronary arteriongraphy(CAG) was measured,among of them,acute coronary artery syndrome (ACS) with 58 cases( ACS group ),stable angina cordis with 25 cases( stable angina cordis group),non-coronary disease with 29 cases(control group).The severity of coronary artery lesion was evaluated by the number of stenosis vessel and Gensini score.They were divided into control group (29 cases),single vessel lesion group (24 cases),double vessel lesion group(26 cases),triple vessel lesion group(33 cases ) according to the number of stenosis vessel and 0-1 score group(29 cases),2-20 scores group(28 cases),21-40 scores group(30 cases),>40 scores group (25 cases) according to the Gensini score.Results The concentrations of serum uric acid in ACS group were higher than those in control group and stable angina cordis group[ (369.61 ± 91.97 ) μ mol/Lvs. (298.33 ±92.46),(330.43 ±87.42)μmol/L] (P <0.05).The concentrations of serum uric acid in control group were lower than those in single vessel lesion group,double vessel lesion group and triple vessel lesion group [(298.33 ±92.46)μmol/L vs. (331.77 ±86.33),(368.24 ±95.21),(396.82 ±94.45) μ mol/L] (P < 0.05).The concentrations of serum uric acid in single vessel lesion group were significantly lower than those in double vessel lesion group and triple vessel lesion group (P < 0.05 ).The concentrations of serum uric acid in 0-1 score group [ (298.33 ± 92.46) μ mol/L] and 2-20 scores group [ (320.77 ± 86.33 ) μ mol/L ] were respectively lower than those in 21-40 scores group [ (366.61 ± 91.97 ) μ mol/L ] and > 40 scores group [ (402.82 ± 91.97 ) μ mol/L] (P < 0.05 ).The concentrations of serum uric acid in > 40 scores group was higher than that in 21-40 scores group (P < 0.05 ).Serum uric acid concentrations was positively correlated with the log of Gensini score (r =0.348,P < 0.05 ).Conclusion The increase in serum uric acid might reflect increase in severity of coronary artery stenosis.