CAJ | 학술논문

目的探讨血尿酸水平与冠心病及其病变严重程度的相关性.方法选取112例行冠状动脉造影的患者,分为3组,急性冠状动脉综合征(ACS)患者58例(ACS组),稳定型心绞痛患者25例(稳定型心绞痛组),非冠心病患者29例(对照组),进行血尿酸测定,冠状动脉病变程度用冠状动脉病变支数及Gensini积分表示,按病变范围分为对照组(29例)、单支病变组(24例)、双支病变组(26例)、三支病变组(33例)；按Gensini积分分为0～1分组(29例)、2～20分组(28例)、21～40分组(30例)、＞40分组(25例).结果 ACS组血尿酸水平显著高于对照组和稳定型心绞痛组[( 369.61±91.97)μmol/L比(298.33±92.46)、(330.43±87.42)μmol/L](P＜ 0.05).对照组血尿酸水平显著低于单支、双支和三支病变组[ (298.33±92.46)μmol/L比(331.77±86.33)、(368.24±95.21)、(396.82±94.45)μmol/L](P＜0.05),单支病变组血尿酸水平显著低于双支病变组和三支病变组(P＜0.05).0～1分组[(298.33±92.46)μmol/L]和2～20分组[(320.77±86.33)μmol/L]血尿酸水平显著低于21～40分组[(366.61 ±91.97) μmol/L]和＞40分组[(402.82±91.97)μ mol/L](P＜0.05).21 ～40分组血尿酸水平低于＞40分组(P＜0.05).血尿酸水平与Gensini积分的对数呈正相关(r=0.348,P＜ 0.05).结论血尿酸与冠状动脉稳定性、狭窄程度以及范围显著相关,有助于临床评价冠心病病变程度及其进展.
목적 탐토혈뇨산수평여관심병급기병변엄중정도적상관성.방법 선취112례행관상동맥조영적환자,분위3조,급성관상동맥종합정(ACS)환자58례(ACS조),은정형심교통환자25례(은정형심교통조),비관심병환자29례(대조조),진행혈뇨산측정,관상동맥병변정도용관상동맥병변지수급Gensini적분표시,안병변범위분위대조조(29례)、단지병변조(24례)、쌍지병변조(26례)、삼지병변조(33례)；안Gensini적분분위0～1분조(29례)、2～20분조(28례)、21～40분조(30례)、＞40분조(25례).결과 ACS조혈뇨산수평현저고우대조조화은정형심교통조[( 369.61±91.97)μmol/L비(298.33±92.46)、(330.43±87.42)μmol/L](P＜ 0.05).대조조혈뇨산수평현저저우단지、쌍지화삼지병변조[ (298.33±92.46)μmol/L비(331.77±86.33)、(368.24±95.21)、(396.82±94.45)μmol/L](P＜0.05),단지병변조혈뇨산수평현저저우쌍지병변조화삼지병변조(P＜0.05).0～1분조[(298.33±92.46)μmol/L]화2～20분조[(320.77±86.33)μmol/L]혈뇨산수평현저저우21～40분조[(366.61 ±91.97) μmol/L]화＞40분조[(402.82±91.97)μ mol/L](P＜0.05).21 ～40분조혈뇨산수평저우＞40분조(P＜0.05).혈뇨산수평여Gensini적분적대수정정상관(r=0.348,P＜ 0.05).결론 혈뇨산여관상동맥은정성、협착정도이급범위현저상관,유조우림상평개관심병병변정도급기진전.
Objective To investigate the correlation between serum uric acid level and severity of coronary artery disease.Methods The concentrations of serum uric acid in 112 patients whom had received coronary arteriongraphy(CAG) was measured,among of them,acute coronary artery syndrome (ACS) with 58 cases( ACS group ),stable angina cordis with 25 cases( stable angina cordis group),non-coronary disease with 29 cases(control group).The severity of coronary artery lesion was evaluated by the number of stenosis vessel and Gensini score.They were divided into control group (29 cases),single vessel lesion group (24 cases),double vessel lesion group(26 cases),triple vessel lesion group(33 cases ) according to the number of stenosis vessel and 0-1 score group(29 cases),2-20 scores group(28 cases),21-40 scores group(30 cases),＞40 scores group (25 cases) according to the Gensini score.Results The concentrations of serum uric acid in ACS group were higher than those in control group and stable angina cordis group[ (369.61 ± 91.97 ) μ mol/Lvs. (298.33 ±92.46),(330.43 ±87.42)μmol/L] (P ＜0.05).The concentrations of serum uric acid in control group were lower than those in single vessel lesion group,double vessel lesion group and triple vessel lesion group [(298.33 ±92.46)μmol/L vs. (331.77 ±86.33),(368.24 ±95.21),(396.82 ±94.45) μ mol/L] (P ＜ 0.05).The concentrations of serum uric acid in single vessel lesion group were significantly lower than those in double vessel lesion group and triple vessel lesion group (P ＜ 0.05 ).The concentrations of serum uric acid in 0-1 score group [ (298.33 ± 92.46) μ mol/L] and 2-20 scores group [ (320.77 ± 86.33 ) μ mol/L ] were respectively lower than those in 21-40 scores group [ (366.61 ± 91.97 ) μ mol/L ] and ＞ 40 scores group [ (402.82 ± 91.97 ) μ mol/L] (P ＜ 0.05 ).The concentrations of serum uric acid in ＞ 40 scores group was higher than that in 21-40 scores group (P ＜ 0.05 ).Serum uric acid concentrations was positively correlated with the log of Gensini score (r =0.348,P ＜ 0.05 ).Conclusion The increase in serum uric acid might reflect increase in severity of coronary artery stenosis.