CAJ | 학술논문

目的评价吸人高低氧联合后程加速超分割放疗对食管癌的临床疗效.方法 74例患者随机分为试验组和对照组.试验组常规分割放疗DT 38～40 Gy后改为DT 1.3～1.4 Gy/次,每天2次,间隔时间＞6 h,中位总剂量DT 64.2 Gy,放疗过程中先后吸入高低浓度氧.对照组常规分割放疗1.8～2.0 Gy/次,每周5次,中位总剂量65.6 Gy.结果获得病例71例.放疗DT30 cy时,试验组完全缓解率(CRR)为31%,对照组ERR为19%(P＞0.05);放疗结束时,试验组CRR为57%,对照组CRR为31%(P＜0.05);放疗结束1个月后,试验组CRR为71%,对照组CRR为33%(P＜0.01);放疗后6个月,试验组CRR为74%,对照组CRR为36%(P＜0.01);试验组6个月局部控制率为91%,对照组为72%(P＜0.05).两组的毒副反应差异元统计学意义.结论吸人高低氧联合后程加速超分割放疗明显提高了Ⅰ～Ⅲ期食管癌的近期疗效及局部控制率,毒副反应可耐受.
목적 평개흡인고저양연합후정가속초분할방료대식관암적림상료효.방법 74례환자수궤분위시험조화대조조.시험조상규분할방료DT 38～40 Gy후개위DT 1.3～1.4 Gy/차,매천2차,간격시간＞6 h,중위총제량DT 64.2 Gy,방료과정중선후흡입고저농도양.대조조상규분할방료1.8～2.0 Gy/차,매주5차,중위총제량65.6 Gy.결과 획득병례71례.방료DT30 cy시,시험조완전완해솔(CRR)위31%,대조조ERR위19%(P＞0.05);방료결속시,시험조CRR위57%,대조조CRR위31%(P＜0.05);방료결속1개월후,시험조CRR위71%,대조조CRR위33%(P＜0.01);방료후6개월,시험조CRR위74%,대조조CRR위36%(P＜0.01);시험조6개월국부공제솔위91%,대조조위72%(P＜0.05).량조적독부반응차이원통계학의의.결론 흡인고저양연합후정가속초분할방료명현제고료Ⅰ～Ⅲ기식관암적근기료효급국부공제솔,독부반응가내수.
Objective To evaluate the efficacy of inspiring carbogen and low concentration oxygen combined with late coupe accelerated hyperfraction radiotherapy on esophageal carcinoma.Methods 74 patients with esophageal carcinoma were randomly divided into two groups:the trial group and the centrol group,which consisted of 37 patients respectively.6MV X-ray was employed in the two groups.The schedule of the trial group was as following:conventional radiotherapy of 1.8～2.0Gy per day was employed during the first phase to a total dose of 38～40Gy,followed by late course accelerated hyperfraetion radiotherapy(twice fractions per day,interval between two fractions more than 6 hours,1.3～1.4Gy per fraction,middle total dose of 64.2Gy).Carbogen and low concentraetion oxygen was inspired during the course of radiation.Results 71 patients were enrolled.At the end of radiation at a total dose of 38～40Gy,complete remission rate(CRR)in the trial group was 31%,whereas that in the control group was 19%(P＞0.05),when the whole radiotherapy was finished,the CRR was 57%and 31%(P＜0.05)respectively,and one month after radiotherapy.the CRR was 71%and 33%respectively(P＜0.01).Six months after radiotherapy,the CRR WaLa 74%and 36%respectively(P＜0.01).Thelocal controlrate of sixmonthswas 91% and 72% respectively in the two groups(P＜0.05).Conclusions Inspiring carbogen and low concentration oxygen combined with late course accelerated hyperfraction radiotherapy may sigllificantly improve short-term efficacy and local control rate in esophageal carcinoma patients in Ⅰ～Ⅲstage.Furthermore,its side effects can be tolerated,and its elongating life time of patients may be prognostic.