中华泌尿外科杂志
中華泌尿外科雜誌
중화비뇨외과잡지
CHINESE JOURNAL OF UROLOGY
2009年
12期
845-847
,共3页
管同郁%孙庆增%戚景光%曹敬毅%吴刚%杨宁%承征宇%梁杰%王乾
管同鬱%孫慶增%慼景光%曹敬毅%吳剛%楊寧%承徵宇%樑傑%王乾
관동욱%손경증%척경광%조경의%오강%양저%승정우%량걸%왕건
经尿道前列腺电切术%再手术%微血管密度%血管内皮生长因子%雄激素受体
經尿道前列腺電切術%再手術%微血管密度%血管內皮生長因子%雄激素受體
경뇨도전렬선전절술%재수술%미혈관밀도%혈관내피생장인자%웅격소수체
Transurethtal resection%prostate%Reoperation%Microvessel density%Vascular endothelial growth factor%Androgen receptor
目的 探讨再次TURP患者前列腺组织微血管密度(MVD)、血管内皮生长因子(VEGF)和雄激素受体(AR)表达的临床意义.方法 再次TURP手术患者50例.选取2次手术标本(再次TURP组),50例首次手术患者标本作为对照组.采用免疫组织化学S-P法检测标本组织中CD_(34)、VEGF、AR的表达,通过血管内皮特异的CD_(34)染色计数MVD值.统计学比较3组标本MVD、VEGF、AR的表达水平.结果 再次TURP组1、2次手术标本和对照组标本MVD值分别为35.83±20.92、32.16±16.65和20.56±6.99,VEGF阳性表达率分别为82.0%(41例)、84.0%(42例)和60.0%(30例),AR阳性表达率分别为84.0%(42例)、88.0%(44例)和64.0%(32例),再次TURP组首次标本MVD值、AR及VEGF阳性表达率均高于对照组,差异有统计学意义(P<0.05);再次TURP组2次手术标本间各指标差异无统计学意义(P>0.05). 结论 BPH患者前列腺组织中高MVD值及AR、VEGF高表达是导致TURP术后复发及再次手术的重要原因之一.
目的 探討再次TURP患者前列腺組織微血管密度(MVD)、血管內皮生長因子(VEGF)和雄激素受體(AR)錶達的臨床意義.方法 再次TURP手術患者50例.選取2次手術標本(再次TURP組),50例首次手術患者標本作為對照組.採用免疫組織化學S-P法檢測標本組織中CD_(34)、VEGF、AR的錶達,通過血管內皮特異的CD_(34)染色計數MVD值.統計學比較3組標本MVD、VEGF、AR的錶達水平.結果 再次TURP組1、2次手術標本和對照組標本MVD值分彆為35.83±20.92、32.16±16.65和20.56±6.99,VEGF暘性錶達率分彆為82.0%(41例)、84.0%(42例)和60.0%(30例),AR暘性錶達率分彆為84.0%(42例)、88.0%(44例)和64.0%(32例),再次TURP組首次標本MVD值、AR及VEGF暘性錶達率均高于對照組,差異有統計學意義(P<0.05);再次TURP組2次手術標本間各指標差異無統計學意義(P>0.05). 結論 BPH患者前列腺組織中高MVD值及AR、VEGF高錶達是導緻TURP術後複髮及再次手術的重要原因之一.
목적 탐토재차TURP환자전렬선조직미혈관밀도(MVD)、혈관내피생장인자(VEGF)화웅격소수체(AR)표체적림상의의.방법 재차TURP수술환자50례.선취2차수술표본(재차TURP조),50례수차수술환자표본작위대조조.채용면역조직화학S-P법검측표본조직중CD_(34)、VEGF、AR적표체,통과혈관내피특이적CD_(34)염색계수MVD치.통계학비교3조표본MVD、VEGF、AR적표체수평.결과 재차TURP조1、2차수술표본화대조조표본MVD치분별위35.83±20.92、32.16±16.65화20.56±6.99,VEGF양성표체솔분별위82.0%(41례)、84.0%(42례)화60.0%(30례),AR양성표체솔분별위84.0%(42례)、88.0%(44례)화64.0%(32례),재차TURP조수차표본MVD치、AR급VEGF양성표체솔균고우대조조,차이유통계학의의(P<0.05);재차TURP조2차수술표본간각지표차이무통계학의의(P>0.05). 결론 BPH환자전렬선조직중고MVD치급AR、VEGF고표체시도치TURP술후복발급재차수술적중요원인지일.
Objective To discuss microvessel density (MVD) and expression of vascular endothelial growth factor(VEGF), androgen receptor(AR) in the prostates of men who received re-operation after TURP. Methods Fifty cases were performed re-TURP (re-TURP group) and the remaining 50 cases served as controls. 150 specimens were collected. Sections were stained for CD34 and VEGF, AR by immuno-histo-chemistry(S-P). Statistical analysis of the results was performed using t-test or Pearson Chi-Square test Results The expression of VEGF, AR and MVD were significantly higher in the re-TURP group compared to controls(P<0. 05),but in re-TURP group, difference in VEGF and AR expression as well as MVD were not found to be significantly different between the first and the second TURP(P>0.05). Conclusion Over expression of VEGF and AR as well as high MVD in prostatic tissue might play an important role in the pathological process of BPH after TURP.
