CAJ | 학술논문

2008年11月至2009年8月,收集河北省11家医院219例社区获得性肺炎住院患者的合格痰标本,采用聚合酶链反应技术检测病原体.125例检出病原体,其中肺炎链球菌检出率最高,占60％ (75/125),病毒感染中甲型流感病毒最常见,占26％(32/125),混合感染占25％( 31/125).≤30岁和51 ～70岁两个年龄段肺炎链球菌检出率较高；有基础疾病的患者流感嗜血杆菌检出率高；肺炎支原体多见于肺炎患者预后研究组(PORT)分级Ⅰ、Ⅱ级的轻症患者；有基础疾病者病毒感染率较高,但两者差异无统计学意义(P＞0.05).说明肺炎链球菌是社区获得性肺炎最常见致病菌,病毒感染在社区获得性肺炎中占据重要位置,其中甲型流感病毒最常见；年龄、基础疾病是影响病原体分布的重要因素.
2008년11월지2009년8월,수집하북성11가의원219례사구획득성폐염주원환자적합격담표본,채용취합매련반응기술검측병원체.125례검출병원체,기중폐염련구균검출솔최고,점60％ (75/125),병독감염중갑형류감병독최상견,점26％(32/125),혼합감염점25％( 31/125).≤30세화51 ～70세량개년령단폐염련구균검출솔교고；유기출질병적환자류감기혈간균검출솔고；폐염지원체다견우폐염환자예후연구조(PORT)분급Ⅰ、Ⅱ급적경증환자；유기출질병자병독감염솔교고,단량자차이무통계학의의(P＞0.05).설명폐염련구균시사구획득성폐염최상견치병균,병독감염재사구획득성폐염중점거중요위치,기중갑형류감병독최상견；년령、기출질병시영향병원체분포적중요인소.
An investigation on pathogens was performed on 219 consecutive adult inpatients with community-acquired pneumonia (CAP) from November 2008 to August 2009 in Hebei Province.Sputum samples from all patients in acute phase were collected for multiplex polymerase chain reaction (PCR) detection. Pathogens were identified in 125 patients. Streptococcus pneumoniae was the most common pathogen isolated in 75 cases (60％) ; influenza A virus was the most common virus isolated in 32 cases (26％) ; and mixed infection were found in 31 patients (25％). Streptococcus pneumoniae species were more frequent among patients aged ≤30 and 51 -70; Haemophilus influenzae species were more frequent among patients with coexisting disease; the percent of Mycoplasma pneumoniae species infections in the lowrisk groups( Ⅰ - Ⅱ ) was higher than patients in the high-risk groups ( Ⅲ - V ).The percent of virus pneumoniae species infections in patients with coexisting disease trended to higher than patients without coexisting disease,but the difference was not statistically significant ( P ＞ 0.05 ).The results indicate that Streptococcus pneumoniae remains the major bacteria,Viruses are frequently detected in CAP with influenza A virus being the most common one; and mixed infection should not be ignored.The age and underlying diseases are important factors influencing the distribution of pathogens.