血管内皮生长因子在终末期肾细胞癌中的表达及其意义
혈관내피생장인자재종말기신세포암중적표체급기의의
Correlation of serum vascular endothelial growth factor with clinical status of advanced renal cell carcinoma
  • 万方数据
    中华实验外科杂志 중화실험외과잡지
    CHINESE JOURNAL OF EXPERIMENTAL SURGERY
    2008年 11期 1485-1486 ,共2页

    钟惟德%梁宇翔%何慧婵%韩兆冬%毕学成%戴奇山%叶永康%陈清标%秦卫军%陈志南%张阳德

    종유덕%량우상%하혜선%한조동%필학성%대기산%협영강%진청표%진위군%진지남%장양덕

    VEGF%肾细胞癌%表达 VEGF%腎細胞癌%錶達
    VEGF%신세포암%표체
    VEGF%Renal cell carcinoma%Expression
    目的 检测终末期肾细胞癌动物模型血管内皮生长因子(VEGF)血浆水平,探讨肾细胞癌侵袭力标记物的相关性.方法 以人肾癌细胞grc-1经皮下植入裸鼠的背部建立终末期细胞癌模型,对实验裸鼠血浆VEGF水平检测,并进行统计学分析.结果 在肿瘤植入度为(4500±2340)ng/L,而对照组裸鼠血浆VEGF浓度几乎未发现变化.结论 VEGF表达强度与肾癌细胞的侵袭能力呈正相关,血浆VEGF浓度越高,肾癌细胞的侵袭能力越强.
    목적 검측종말기신세포암동물모형혈관내피생장인자(VEGF)혈장수평,탐토신세포암침습력표기물적상관성.방법 이인신암세포grc-1경피하식입라서적배부건립종말기세포암모형,대실험라서혈장VEGF수평검측,병진행통계학분석.결과 재종류식입도위(4500±2340)ng/L,이대조조라서혈장VEGF농도궤호미발현변화.결론 VEGF표체강도여신암세포적침습능력정정상관,혈장VEGF농도월고,신암세포적침습능력월강.
    Objective To investigate the clinicopathologic characteristics of serum vascular endo-thelial growth factor (VEGF) expression in advanced renal cell carcinoma (RCC) ,and to evaluate its cor-relation with the progression of advanced RCC. Methods Human RCC cell line grc-1 was implanted sub-cutaneouly into back of BALB/c mice in order to construct model of RCC. Serum VEGF in peripheral blood samples was analyzed in treatment and control groups by using a sandwich enzyme linked immunoadsordent assay. Results Serum VEGF level in RCC mouse models [(4500±2340) ng/L] was significantly higher than that in the control group. Conclusion VEGF expression level is positively correlated with the inva-sivaness of RCC.
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